TY - JOUR AU - Kandemir, Nefise AU - Kenanoglu, Sercan AU - Gultekin, Murat AU - Gokce, Nuriye AU - Akalin, Hilal AU - Taşçıoğlu, Nazife AU - Mirza, Meral AU - Koseoglu, Emel AU - Dundar, Munis PY - 2021/10/01 Y2 - 2024/03/29 TI - Propranolol significantly reduced DNA polymerase β expression in patients with essential tremor JF - Universa Medicina JA - Univ Med VL - 40 IS - 3 SE - Original Articles DO - 10.18051/UnivMed.2021.v40.207-215 UR - https://univmed.org/ejurnal/index.php/medicina/article/view/1197 SP - 207-215 AB - <p><strong>Background</strong> <br />Essential tremor (ET) is the most common movement disorder. Propranolol is a first-line medication for ET. We aimed to evaluate the effect of propranolol on the expression of poly (ADP-ribose) polymerase 1 (PARP1) and DNA polymerase beta (POLB) genes, which are known to be related to neurodegenerative diseases, in patients with ET.</p><p><strong>Methods</strong><br />Thirty-five healthy volunteers and thirty-five patients followed up with essential tremors were included in a non-randomized control experimental study. Expressions of PARP1 and POLB genes were compared between the control group and the patient group. In addition, pre- and post-treatment gene expression levels and Fahn-Tolosa-Marin tremor scale values of the patient group were compared after 8 weeks of propranolol treatment. The Wilcoxon rank and Mann Whitney U tests were used to analyze the data.</p><p><strong>Results</strong><br />At baseline, PARP1 expression was significantly lower in the ET group than in the control group. (p&lt;0.001). POLB gene expression was significantly higher in the pre-treatment ET group than in the controls (p&lt;0.05). There was no significant difference in PARP1 expression levels before and after 8 weeks of propranolol treatment. POLB gene expression was significantly higher in the pre-treatment group than in the post-treatment group (p&lt;0.001).</p><p><strong>Conclusion</strong><br />Propranolol significantly decreased POLB gene expression but there was no significant difference in PARP1 gene expression levels in the patient group, after 8 weeks of propranolol treatment.</p> ER -