TY - JOUR AU - Hassan, Irmawati AU - Tarcisia, Twidy AU - Agnestina, Agnestina AU - Cornain, Santoso AU - Nasar, I Made PY - 2013/12/07 Y2 - 2024/03/28 TI - Ki-67 marker useful for classification of malignant invasive ductal breast cancer JF - Universa Medicina JA - Univ Med VL - 32 IS - 3 SE - Review Article DO - 10.18051/UnivMed.2013.v32.179-186 UR - https://univmed.org/ejurnal/index.php/medicina/article/view/92 SP - 179-186 AB - BACKGROUND <br />Breast cancer is an important health problem in the world. Uncontrolled cell proliferation represents a malignant characteristic of neoplasia such as breast cancer, and can be examined immunohistochemically by measuring the Ki-67 proliferative marker. The objective of this study was to determine the role of Ki-67 for classification of the degree of malignancy in women with invasive ductal breast cancer.<br /><br />METHODS<br />A cross-sectional study was conducted on 20 women with invasive ductal breast cancer. The samples were immuno-histochemically tested for Ki-67 using anti-Ki-67 primary antibody. The Ki-67 proliferative index was determined by enumerating the proportion of Ki-67 positive nuclei among the total number of cells in ten areas observed at 400x magnification, using a 20% cut-off value to distinguish between low and high proliferative indices. Statistical analysis was by means of the chi-square test.<br />    <br />RESULTS<br />Seventy five persent of the high grade malignancies had a high Ki-67 proliferative index (&gt;20%), while only 12.5% of the low grade malignancies had a high Ki-67 index (&gt;20%). The difference in grade malignancy was statistically significant (p=0.022), whereas tumor size was not associated with a statistically significant difference in Ki-67 index (p=0.648). <br /><br />CONCLUSION<br />The study showed that invasive ductal breast cancer with high Ki-67 index was significantly associated with high grade of malignacy. The high Ki-67 marker index can be used for classification of the grade of malignancy of invasive ductal breast cancer. ER -