Cortisol level decreases natural killer cell activity among women with aircraft noise

Main Article Content

Hartono Hartono

Abstract

One of the impacts of exposure to noise is stress. Natural killer (NK) cells are one of the leukocyte subsets that are responsive to physiological and psychological stress. The objective of the present research was to determine the relationship between cortisol levels and NK cell activity among women with aircraft noise stress in the area of Adi Sumarmo Airport, Solo. This study was an analytical survey with a cross sectional design. The number of subjects was 39, who were divided into 3 groups of 13 subjects each. Groups 1 to 3 were exposed to noise levels of 92.29 dB, 71.79 dB and 52.17 dB, respectively. The sample was taken using simple random sampling. The data were analyzed by Pearson correlation test and Anova followed by post hoc test using LSD test. The Anova test showed that there were significant differences in circulating cortisol levels among all groups (p = 0.018). The Pearson correlation test showed that there was a positive association between circulating cortisol levels and the number of NK cells (r = 0.547; p< 0.05) and a negative association between circulating cortisol levels and NK cell activity (r = - 0.578; p < 0.05). This study indicated that cortisol levels decreased NK cell activity among women with exposure to aircraft noise. Women who experienced aircraft noise stress showed increased cortisol levels and decreased NK cells activity.

Article Details

How to Cite
Hartono, H. (2016). Cortisol level decreases natural killer cell activity among women with aircraft noise. Universa Medicina, 29(3), 153–161. https://doi.org/10.18051/UnivMed.2010.v29.153-161
Section
Review Article

References

Passchier VW, Passchier WF. Noise exposure and public health. Environ Health Perspect 2000;108:123-31.

Haines MM, Stansfeld SA, Job Soames RF, Berglund B, Head J. A follow-up study of effects of chronic aircraft noise exposure on child stress responses and cognition. Inter J Epidemiol 2001; 30:839-45.

Spreng M. Central nervous system activation by noise. Noise Health 2000;7:49-57.

Ader R. On the Development of psychoneuroimmunology. Euro J Pharmacol 2000;405:167-76.

Glaser R, Kiecolt GJ. Stress damage immune system and health. Discov Med 2005;5: 165-9.

Padgett D, Glaser R. How stress influences the immune response.Trends Immunol 2003;24:444-8.

Ronald DE. Noise, brain and stress. Endocrine Reg 2003;37:51-68.

Stansfeld SA, Matheson MP. Noise pollution: non-auditory effects on health. British Med Bull 2003;68:243-57.

Melamed S, Luz J, Green MS. Noise exposure, noise annoyance and their relation to psychological distress, accident and sickness absence among blue-collar workers-the Cordis Study. Lsr J Med Sci 1992;28:629-35.

Cooper MA, Fehniger TA, Caligiuri MA. The biology of human natural killer-cell subsets. Trends Immunol 2001;22:633-40.

Kiecolt GJ, Robles TF, Heffner KL, Loving TJ, Glaser R. Psycho-oncology and cancer: psychoneuroimmunology and cancer. Euro Society Med Oncol 2002;31:165-9.

Megan AC, Todd AF, Sarah CT, Kenneth SC, Bobak AG, Tariq G, et al. Human natural killer cells: a unique innate immunoregulatory role for the CD56 bright subset. Blood 2001;97:3146-51.

Morikawa Y, Higashiguchi KK, Tanimoto C, Hayashi M, Oketani R, Miura K, et al. Cross-sectional study on the relationship of job stress with Natural Killer cell activity and Natural Killer cell subsets among healthy nurses. J Occupl Health 2005;47:378-83.

Suzui M, Kawai T, Kimura H, Takeda K, Yagita A, Okumora K, et al. Natural killer cell lytic activity and CD56dim and CD56bright cell distribution during and after intensive training. J Appl Physiol 2004;96:2167-73.

Kanemi O, Zhang X, Sakamoto Y, Nagatomo R. Acute stress reduces intraparenchymal lung natural killer cells via beta-adrenergic stimulation. Clin Exp Immunol 2005;139:25-34.

Nagao FM, Takeda K, Yagita H, Okumura K. Mobilization of NK cells by exercise: down-modulation of adhesion molecules on NK cells by catecholamines. Am J Physiol Regulatory Integrative Comp Physiol 2000; 279:1251-6.

Hartono. The effect of aircraft noise exposure to the number of lymphocytes among people in the area of Adi Sumarmo airport Solo. Environ 2006; 7:20-4.

Hartono, Isna Q, Margono. The effect of aircraft noise exposure on the histologic structure of duodenal layer in Rat (Rattus norvegicus). Environ 2007;8:33-6.

Andalib A, Rezaie A, Oreizy F, Shafiei K, Baluchi S. A study on stress, depression and NK cytotoxic potential in women with recurrent spontaneous abortion. Iran J Allergy Asthma Immunol 2006;5:9-16.

Cheng Z, Ariizumi M. Modulation of immune functions and oxidative status induced by noise stress. J Occup Health 2007;49:32-8.

Dhanalakshmi S, Srikumar R, Manikandan S, Parthasarathy NJ, Devi RS. Antioxidant property of Triphala on cold stress induced oxidative stress in experimental Rats. J Health Science 2006;52: 843-7.

Guyton AC, Hall JE. Textbook of medical physiology. 11th ed. Pennsylvania: Elsevier Inc.; 2006.

Srikumar R, Parthasarathy NJ, Manikandan S, Muthuvel A, Rajamani R, Sheeladevi R. Immunomodulatory effect of Thripala during experimentally induced noise stress in albino rats. J Health Science 2007;53:142-5.

Loza MJ, Perussia B. Differential regulation of NK cells proliferation by type I dan type II IFN. J Immunol 2004;16:23-33.

Gan X, Zhang L, Solomon GF, Bonavida B. Mechanism of norepinephrine-mediated inhibition of human NK cytotoxic functions: inhibition of cytokine secretion, target binding, and programming for cytotoxicity. Brain Behav Immun 2002;16:227–46.

Otagiri A, Wakabayashi I, Shibasaki T. Selective corticotropin-releasing factor Type 1 receptor antagonist blocks conditioned fear-induced release of norepinephrine in the hypothalamic paraventricular nucleus of rats. J Neuroendocrinol 2000;12:1022-6.

Kehrl JH, Ducovich M, Whalen G, Katz P, Fauci AS, Green WC. Novel interleukin-2 (IL-2) receptor appears to mediate IL-2 induced activation of natural killer cells. J Clin Inves 1998;81:200-5.