Low testosterone level increases fasting blood glucose level in adult males

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Published: Dec 14, 2012
DOI: https://doi.org/10.18051/UnivMed.2012.v31.200-207 Universa Medicina
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Keywords:
Total testosterone sex hormone binding globulin blood glucose male

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Suweino Suweino
Department of Biochemistry, Faculty of Medicine, Trisakti University
ML Eddy Parwanto
Department of Biology, Faculty of Medicine, Trisakti University
David Tjahjadi
Department of Histology, Faculty of Medicine, Trisakti University

Abstract

BACKGROUND Total testosterone (TT) levels in males decrease with age. There has been a vigorous debate on the extent to which low testosterone causally contributes to diabetes and its complications. The aim of the present study was to determine the relationship between sex hormones and blood glucose levels in adult males. METHODS A cross-sectional study involving 259 males aged 41 - 70 years was conducted at Cilandak Subdistrict, South Jakarta. Sex hormone binding globulin (SHBG) and testosterone levels were measured by means of electro–chemiluminescent immunoassay (ECLIA), while blood glucose levels were measured enzymatically using a spectrophotometer. Free testosterone index (FTI) and body massa index (BMI) were calculated. Inter-variable relationships were tested by Pearson correlation analysis, followed by multiple linear regression analysis to determine the most influential factor on fasting blood glucose levels. RESULTS BMI was positively correlated with fasting blood glucose, but the correlation was statistically not significant (r=0.105; p=0.106). In contrast, total testosterone (TT) (r=-0.258; p=0.000) and SHBG (r=-0.193; p=0.02) had a significant negative correlation with fasting blood glucose level. Multiple linear regression showed that TT was the most influential factor on fasting blood glucose level (â=-0.044; p=0.008). CONCLUSIONS Low total testosterone level may increase fasting blood glucose level in adult males. SHBG levels did not predict fasting blood glucose levels.Assessment of testosterone in middle-aged men may allow early intervention for diabetes mellitus.

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How to Cite
Suweino, S., Parwanto, M. E., & Tjahjadi, D. (2012). Low testosterone level increases fasting blood glucose level in adult males. Universa Medicina, 31(3), 200–207. https://doi.org/10.18051/UnivMed.2012.v31.200-207
Issue
Vol. 31 No. 3 (2012)
Section
Review Article

The journal allows the authors to hold the copyright without restrictions and allow the authors to retain publishing rights without restrictions.

References

Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005;26:833–76.

Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, Salonen R, et al. Sex hormones, inflammation and the metabolic syndrome: a population-based study. Eur J

Endocrinol 2003;149:601–8.

Mawi M, Nirmalasari. High free testosterone index increases lung function in adult males. Univ Med 2012;31:113-9.

Agledahl I, Skjærpe PA, Hansen JB, Svartberg J. Low serum testosterone in men is inversely associated with non-fasting serum triglycerides: the Tromsø study. Nutr Metab Cardiovasc Dis 2008;18:256–62.

Cowie CC, Rust KF, Byrd-Holt DD, Gregg EW, Ford ES, Geiss LS, et al. Prevalence of diabetes and high risk for diabetes using A1C criteria in the U.S. population in 1988–2006. Diabetes Care

;33:562–8.

Dhindsa S, Prabhakar S, Sethi M, Bandyopadhyay A, Chaudhuri A, Dandona P. Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. J Clin

Endocrinol Metab 2004;89:5462–8.

Svartberg J, von Mu¨ hlen D, Schirmer H, Barrett-Connor E, Sundfjord J, Jorde R. Association of endogenous testosterone with

blood glucose level in men : the Tromsø study. Eur J Endocrinol 2004;150:65–71.

Laaksonen DE, Niskanen L, Punnonen K, Nyysso¨nen K, Tuomainen TP, Valkonen VP, et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and

diabetes in middle-aged men. Diabetes Care 2004;27:1036–41.

Simon D, Charles MA, Lahlou N, Nahoul K, Oppert JM, Gouault-Heilmann M, et al. Androgen therapy improves insulin sensitivity

and decreases leptin level in healthy adult men with low plasma total testosterone: a 3-month randomized placebo-controlled trial. Diabetes Care 2001;24:2149–51.

Kapoor D, Goodwin E, Channer K, Jones TH. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in

hypogonadal men with type 2 diabetes. Eur J Endocrinol 2006;154:899–906.

Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H, Eriksson KF, et al. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care

;28:1636–42.

Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB. Low sex hormonebinding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in

nonobese men. J Clin Endocrinol Metab 2006;91:843–50.

Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and metaanalysis. JAMA 2006;295:1288–99.

Corona G, Monami M, Rastrelli G, Aversa A, Sforza A, Lenzi A, et al. Type 2 diabetes mellitus and testosterone: a meta-analysis study. Int J Androl 2010. doi:10.1111/j.1365-2605.2010.01117.x.

Vermeulen A, Verdonck L, Kaufman JM. Acritical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666–72.

Grossman M, Thomas MC, Panagiotopoulos S, Sharpe K, MacIsaac RJ, Clarke S, et al. Low testosterone levels are common and associated with insulin resistance in men with diabetes. J Clin Endocrinol Metab 2008;93:1834–40.

Kim MJ, Rolland Y, Cepeda O, Gammack JK, Morley JE. Diabetes mellitus in older men. Aging Male 2006;9:139-47. Doi: 10.1080/13685530600907977.

Vermeulen A, Kaufman JM, Goemaere S, van Pottelberg I. Free testosterone in elderly men. Aging Male 2002;5:98–102.

Muller M, den Tonkelaar I, Thijssen JH, Grobbee DE, van der Schouw YT. Endogenous sex hormones in men aged 40–80 years. Eur J Endocrinol 2003;149: 583–9.

Halmenschlager G, Rhoden EL, Riedner CE. The influence of age on bioavailable and free testosterone is independent of body mass index and glucose levels. World J Urol 201;29:541–6.

DOI 10.1007/s00345-011-0724-x.

Ding EL, Song Y, Manson JE, Hunter DJ, Lee CC, Rifai N, et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 2009;361:1152–63.

Lakshman KM, Bhasin S, Araujo AB. Sex hormone-binding globulin as an independent predictor of incident type 2 diabetes mellitus in men. J Gerontol A Biol Sci Med Sci 2010;65:503–9.

Bremner WJ, Vitiello MV, Prinz PN. Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metabol 2006;56:1278–81.

Bolelli G, Muti P, Micheli A, Sciajno R, Franceschetti F, Krogh V. Correlation studies of testosterone hormones level in serum with the development of diabetes. Epidemiol Biomark

Prev 2005;4:509–13.

Kaplan SA, Meehan AG, Shah A. The age related decrease in testosterone is significantly Suweino, Parwanto, Tjahjadi Testosteron increases blood glucose exacerbated in obese men with the metabolic syndrome. What are the implications for the

relatively high incidence of erectile dysfunction observed in these men? J Urol 2006;176:1524–8.

Kapoor D, Aldred H, Clark S. Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes. Diabetes Care 2007;30:911-7