Low neutrophil-to-lmphocyte ratio decreases risk of coronavirus disease in pregnant women

Main Article Content

Nutria Widya Purna Anggraini
Sri Sulistyowati


Coronavirus Infection 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an emergency condition for global public health. Early detection of COVID-19 in pregnant women is needed. The neutrophil-to-lymphocyte ratio (NLR), as a marker of viral inflammatory response, is used to determine the presence of a viral or bacterial infection, both acute and chronic. The objective of this study was to determine the relationship between NLR and the polymerase chain reaction (PCR) swab test results in pregnant women with suspected coronavirus disease 2019.

A cross-sectional study was conducted on 9 pregnant women with suspected COVID-19. The subjects were inpatients at Moewardi Hospital Surakarta from 19 April-19 May 2020, who had rapid tests, complete blood examinations, and PCR swab tests. The NLR was categorized based on early warning scores according to research developed at Zhejiang University, with cut-off point 5.8. Diagnosis of COVID-19 was confirmed by PCR swab tests. Relation between NLR   and PCR swab results was analyzed by the prevalence ratio.

Two patients (22.2%) had NLR >5.8, with positive swab results in both (100%). Seven patients with NLR <5.8 had positive swabs in only one (33.3%). The relationship between NLR and PCR swab test results showed a prevalence ratio of 0.143 (95% CI 0.023-0.877).

Pregnant women with NLR < 5.8 had a decreased risk of COVID-19. Routine blood examination is more suitable for finding pregnant women with suspected COVID-19.

Article Details

How to Cite
Anggraini, N. W. P., & Sulistyowati, S. (2020). Low neutrophil-to-lmphocyte ratio decreases risk of coronavirus disease in pregnant women. Universa Medicina, 39(2), 88–96. https://doi.org/10.18051/UnivMed.2020.v39.88-96
Original Articles
Author Biographies

Nutria Widya Purna Anggraini, Department of Obstetric and Gynekology, Faculty of Medicine, Universitas Sebelas Maret/ RSUD Dr. Moewardi, Surakarta

Department of Obstetric and Gynekology,
Faculty of Medicine, Universitas Sebelas Maret/ RSUD Dr. Moewardi, Surakarta

Sri Sulistyowati, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret/ RS Universitas Sebelas Maret, Surakarta

Department of Obstetric and Gynekology,
Faculty of Medicine, Universitas Sebelas Maret/ RS Universitas Sebelas Maret, Surakarta


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