Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults

Main Article Content

Winda Mulyamin
Liong Boy Kurniawan
Endy Adnan
Yuyun Widaningsih
Irfan Idris
Arif Santoso
Ika Yustisia

Abstract

BACKGROUND
High-sensitivity C-reactive protein (hsCRP) has been widely accepted as a predictor of future cardiovascular risk that reflects a microinflammatory state. Obesity linked to microinflammation increases the prevalence of metabolic disorders and cardiovascular diseases. This study aimed to determine the association between several obesity indices namely body mass index (BMI), waist circumference (WC), body fat percentage (fat), and visceral fat (VF) with hsCRP in non-diabetic adults.

METHODS
This was a cross-sectional study performed on 80 non-diabetic adults with ages ranging from 20-40 years. The obesity indices BMI, WC, body fat percentage, and VF were measured. We then measured the hsCRP levels using an immunoturbidimetric method. Simple and multiple linear regression tests were used to analyze the association between obesity indices and hsCRP levels.

RESULTS
Mean of log BMI, log WC, and log VF was 1.41 ± 0.08 kg/m2, 1.93 ± 0.06 cm, and 0.95 ± 0.27 units, respectively. Simple linear regression tests showed that log BMI (â=3.506; p<0.001), log WC (â=3.672; p<0.001), log VF (â=0.833; p<0.001), and log systolic blood pressure (â=3.739; p=0.024) had a significant positive correlation with log hsCRP levels. Further multiple linear regression test showed that log BMI (â=3.772; Beta=0.674; p<0.001) had the greater effect on log hsCRP levels compared to other indices.

CONCLUSIONS    
BMI had a greater influence on hsCRP levels compared to other obesity indices in non-diabetic adults. Body mass index can be used as a better index in predicting hsCRP levels compared to other indices.

Article Details

How to Cite
Mulyamin, W., Kurniawan, L. B., Adnan, E., Widaningsih, Y., Idris, I., Santoso, A., & Yustisia, I. (2021). Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults. Universa Medicina, 40(1), 22–28. https://doi.org/10.18051/UnivMed.2021.v40.22-28
Section
Original Articles
Author Biographies

Winda Mulyamin, Aging and Regenerative Medicine Concentration, Biomedical Magister Programme, Hasanuddin University, Makassar

Aging and Regenerative Medicine Concentration, Biomedical Magister Programme

Liong Boy Kurniawan, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar

Department of Clinical Pathology

Yuyun Widaningsih, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar

Department of Clinical Pathology

Irfan Idris, Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar

Department of Physiology

Ika Yustisia, Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar

Department of Biochemistry

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