Random blood glucose level as predictor of cognitive impairment in elderly
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Abstract
Nutritional deficits have been linked to poor cognitive function and are highly prevalent in the elderly. Several factors associated with cognitive function have been studied, but the results were inconclusive. The objective of this study was to determine the relationship between blood glucose level and cognitive impairment in the elderly.
Methods
A cross-sectional study was conducted and a total of 109 elderly were included in the study. Research subjects were selected using consecutive non-random sampling from the Tebet sub-district in South Jakarta. Random blood glucose level was assessed using glucose strips (Nesco). Cognitive function was measured with the Montreal Cognitive Assessment (MoCA) and Informant Questionnaire on Cognitive Decline in Elderly (IQCODE) questionnaire. The relationship between blood glucose levels and cognitive function was analyzed by means of multiple linear regression analysis.
Results
The mean age of the elderly was 67.95 ± 6.42 years, length of formal education was 10.12 ± 5.88 years, and mean random blood glucose level was 137.41 ± 70.25 mg/dL. Multiple regression analysis showed that length of formal education (â= 0.769; p=0.000) and random blood glucose levels (â=0.016; p=0.014) were significantly associated with cognitive function.
Conclusion
Cognitive function is negatively affected by high blood glucose, thus random blood glucose level can be used to predict cognitive impairment.
Article Details
The journal allows the authors to hold the copyright without restrictions and allow the authors to retain publishing rights without restrictions.
References
World Health Organization. Active ageing: a policy framework. Geneva: World Health Organization;2002.
Soejono CH, Setiati S, Nasrun MWS, Silaswati S. Pedoman pengelolaan kesehatan pasien geriatri untuk dokter dan perawat. Edisi Pertama. Jakarta: Pusat Informasi dan Penerbit Bagian Ilmu Penyakit Dalam FKUI; 2004.
Badan Pusat Statistik. Penduduk menurut kelompok umur dan jenis kelamin 2010. Available at: http://www.bps.go.id/aboutus.php? sp=1. Accessed October 1, 2011.
Greenwood CE. Dietary carbohydrate, glucose regulation, and cognitive performance in elderly persons. Nutr Rev 2003;61:S68-74.
Khairani R. Prevalence of diabetes mellitus and the relationship with quality of life of older people in the community. Univ Med 2007;26: 18-26.
Durga J, van Boxtel MP, Schouten EG. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369:208–16.
Rafinsson SB, Deary IJ, Smith FB, Whiteman MC, Fowkes FGR. Cardiovascular diseases and decline in cognitive function in an elderly community population: the Edinburgh artery study. Am Psychosom Med 2007;69:425-34.
Allen KV, Frier BM, Strachan MWJ. The relationship between type 2 diabetes and cognitive dysfunction: longitudinal studies and their methodological limitations. Eur J Pharmacol 2004;490:169–75.
Hassing LB, Hofer SM, Nilsson SE, Berg S, Pedersen NL, McClearn G, et al. Comorbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study. Age Ageing 2004;33:355–61.
Kanaya AM, Barrett-Connor E, Gildengorin G, Yaffe K. Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort. Arch Intern Med 2004;164:1327–33.
Janson J, Laedtke T, Parisi JE, O’Brien P, Petersen RC, Butler PC. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 2004;53: 474–81.
Salim OC, Kusumaratna RK, Sudharma NI, Hidayat A. Knee height as a predictor for stature in the elderly. Univ Med 2006;25:15-21.
World Health Organization. Appropriate body mass index for Asian population and its implicationfor policy and intervention strategies. Lancet 2004;363:157-63.
Smith T, Gildeh N, Holmes C. The montreal cognitive assessment: validity and utility in a memory clinical setting. Can J Psychiatry 2007; 52:329-32.
Jorm AF. The informant questionnaire on cognitive decline in the elderly (IQCODE): a review. Int Psychogeriatr 2004;16:1-19.
Bruce DG, Davis WA, Casey GP, Starkstein SE, Clarnette RM, Foster JK, et al. Predictors of cognitive impairment and dementia in older people with diabetes. Diabetologia 2008;51:241–8. DOI 10.1007/s00125-007-0894-7.
Rolandsson O, Backestrom A, Eriksson S, Hallmans G, Nilsson LG. Increased glucose levels are associated with episodic memory in nondiabetic women. Diabetes 2008;57:440–3.
Whitmer RA, Sidney S, Selby J, Johnston SC, Yaffe K. Midlife cardiovascular risk factors and risk of dementia in late life. Neurology 2005;64: 277–81.
Awad N, Gagnon M, Desrochers A, Tsiakas M, Messier C. Impact of peripheral glucoregulation on memory. Behav Neurosci 2002;116:691–702.
Euser SM, Sattar N, Witteman JCM, Bollen LEM, Sijbrands EJG, Hofman A, et al. For Prosper and the Rotterdam study. A prospective analysis of elevated fasting glucose levels and cognitive function in older people. Diabetes 2010;59:1601-7.
van Oijen M, Okereke OI, Kang JH, Pollak MN, Hu FB, Hankinson SE, et al. Fasting insulin levels and cognitive decline in older women without diabetes. Neuroepidemiology 2008;30: 174-9.
Xu W, Caracciolo B, Wang HX, Winblad B, Bäckman L, Qiu C, et al. Accelerated progression from mild cognitive impairment to dementia in people with diabetes. Diabetes 2010;59:2928–35.
Ng TP, Feng L, Niti M, Yap KB. Albumin, haemoglobin, BMI and cognitive performance in older adults. Age Ageing 2008;37:423–9.
Gustafson D. Adiposity indices and dementia. Lancet Neurol 2006;5:713–20.
Kuo HK, Jones RN, Milberg WP. Cognitive function in normal-weight, overweight, and obese older adults: an analysis of the advanced cognitive training for independent and vital elderly cohort. J Am Geriatr Soc 2006;54:97–103.
Stewart R, Masaki K, Xue QL. A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol 2005;62:55–60.
Buchman AS, Wilson RS, Bienias JL. Change in body mass index and risk of incident Alzheimer disease. Neurology 2005;65:892–7.
Mackinnon A, Mulligan R. Combining cognitive testing and informant report to increase accuracy in screening for dementia. Am J Psychiatry 1998; 155:1529-35.
Ashford JW. Screening for memory disorders, dementia and Alzheimer’s disease. Aging Health 2008;4:399-432.