Comparison of matrix metalloproteinase-9 and E-cadherin expression in early- and late-onset preeclampsia

Main Article Content

Tjam Diana Samara
https://orcid.org/0000-0003-0610-0638
Heri Wibowo
https://orcid.org/0000-0001-7708-5135
Isabella Kurnia Liem
https://orcid.org/0000-0002-0138-2659
Ani Retno Prijanti
https://orcid.org/0000-0003-0663-2714
Andrijono Andrijono

Abstract

BACKGROUND
Preeclampsia (PE) is one of the most common pregnancy complications worldwide. Turnover of villous trophoblast is affected by impaired placental perfusion in preeclampsia. Among the various factors that influence pro and antiangiogenic factors in trophoblast invasion of PE are E-cadherin and matrix metalloproteinase-9 (MMP-9). The current classification scheme differentiates PE into two variants early-onset (EO) and late-onset (LO) PE. The aim of this study was to compare MMP-9 and E-cadherin expression between early- (EO) and late-onset (LO) PE.


METHODS
This study used a cross-sectional design involving 26 women with gestational age <34 weeks (EO) and 38 women with gestational age ≥34 weeks (LO) from PE patients. Placentas born to preeclamptic mothers were taken in the form of small pieces of the maternal side to measure the levels of MMP-9 and E-cadherin by the ELISA method. Statistical analysis was assessed using the Mann Whitney and independent t-test with a significant p value <0.05.


RESULTS
Semiquantitative proteinuria levels were significantly higher in EO-PE group compared to LO-PE group (p=0.000). Mean E-cadherin levels were significant lower in the EO-PE group (125.94 ± 54.22 pg/mg) compared to LO-PE group (157.95 ± 54.12 pg/mg) (p=0.024). However, there was no significance difference in median MMP-9 levels between EO-PE group and LO-PE group (p=0.376).


CONCLUSION
This study demonstrate that E-cadherin had lower levels in preeclampsia patients who gave birth <34 weeks. This study indicated that lower levels of e-cadherin can lead to early delivery in preeclampsia patients.

Article Details

How to Cite
Samara, T. D. ., Wibowo, H. ., Liem, I. K. ., Prijanti, A. R. ., & Andrijono, A. (2021). Comparison of matrix metalloproteinase-9 and E-cadherin expression in early- and late-onset preeclampsia. Universa Medicina, 40(3), 200–206. https://doi.org/10.18051/UnivMed.2021.v40.200-206
Section
Original Articles
Author Biographies

Tjam Diana Samara, Anatomy Department, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia

Biomedical Science Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Heri Wibowo, Parasitology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Biomedical Science Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Isabella Kurnia Liem, Anatomy Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Biomedical Science Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Ani Retno Prijanti, Biochemistry and Molecular Biology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Biomedical Science Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Andrijono Andrijono, Obstetric and Gynaecologist Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Biomedical Science Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

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