Being aware of the neurological manifestations of COVID-19 infection

Main Article Content

Basak Atalay


The novel coronavirus disease- 2019 (COVID-19) is first reported from China, and unfortunately, no longer restricted, and spreads in all geographies.(1) The main symptoms of COVID-19 infection are respiratory tract related. Infected patients usually have symptoms such as fever, sore throat, and fatigue, and they may have atypical symptoms like headache, seizure, anosmia, stroke, and even impaired consciousness. Strong evidence of an association between COVID-19 infection and neurological manifestations has been reported. Besides, the neurologic manifestations may be the initial presentation of COVID-19 infection.

Article Details

How to Cite
Atalay, B. (2021). Being aware of the neurological manifestations of COVID-19 infection. Universa Medicina, 40(3), 187–189.


Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382:727-33. doi:10.1056/NEJMoa2001017.

Guan WJ, Ni ZY, Hu Y, et al. on behalf of the China Medical Treatment Expert Group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382:1708-20. doi: 10.1056/NEJMoa2002032.

Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). J Gen Intern Med 2020;35:1545-9. doi: 10.1007/s11606-020-05762-w.

Gavriatopoulou M, Ntanasis-Stathopoulos I, Korompoki E, et al. Emerging treatment strategies for COVID-19 infection. Clin Exp Med 2021;21:167-79. doi: 10.1007/s10238-020-00671-y.

Collantes MEV, Espiritu AI, Sy MCC, Anlacan VMM, Jamora RDG. Neurological manifestations in COVID-19 infection: a systematic review and meta-analysis. Can J Neurol Sci 2021;48:66-76. doi: 10.1017/cjn.2020.146.

Singhania N, Bansal S, Singhania G. An atypical presentation of novel coronavirus disease 2019 (COVID-19). Am J Med 2020;133:e365-e6. doi: 10.1016/j.amjmed.2020.03.026.

Katal S, Balakrishnan S, Gholamrezanezhad A. Neuroimaging and neurologic findings in COVID-19 and other coronavirus infections: a systematic review in 116 patients. J Neuroradiol 2021;48:43-50. doi: 10.1016/j.neurad.2020.06.007.

Mankad K, Perry MD, Mirsky DM, Rossi A. COVID-19: a primer for neuroradiologists. Neuroradiology 2020;62:647-8. doi: 10.1007/s00234-020-02437-5.

Mehta P, McAuley DF, Brown M, et al. on behalf of the HLH Across Speciality Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020;395:1033-4. doi: 10.1016/S0140-6736(20)30628-0.

Ma J, Xia P, Zhou Y, et al. Potential effect of blood purification therapy in reducing cytokine storm as a late complication of critically ill COVID-19. Clin Immunol 2020 ;214:108408. doi: 10.1016/j.clim.2020.108408.

Aghagoli G, Gallo Marin B, Katchur NJ, Chaves-Sell F, Asaad WF, Murphy SA. Neurological involvement in COVID-19 and potential mechanisms: a review. Neurocrit Care 2020:1–10. doi: 10.1007/s12028-020-01049-4.