Risk factors of early onset type 2 diabetes mellitus in young adults ≤ 40 years old
Main Article Content
Abstract
Background
The global prevalence of type 2 diabetes mellitus (T2DM) in adolescents and young adults is dramatically increasing. The aim of this study was to explore numerous risk factors for the occurrence of Pre-DM or T2DM in subjects aged ≤40 years.
Methods
A cross-sectional study was conducted involving 100 subjects (50 subjects in the Pre-DM/T2DM group and 50 subjects in the Non Pre-DM/T2DM group). Main inclusion criteria: age ≤40 years, registered in our Diabetes and Endocrine Clinic. Data extracted included demographic, lifestyle, anthropometric, psychosocial, and family history data. Statistical analysis by binary logistic regression model. Results were considered significant at p<0.05
Results
There were no differences in demographic variables between the two groups. Multivariate analysis showed that cigarette smoking [aOR 3.17 (95% CI: 1.11-11.28)], hypertension [aOR 2.48 (95% CI: 1.23-7.19)] obesity [aOR 5.11 (95% CI: 2.12-8.21)], history of excessive calorie intake [aOR 3.40 (95% CI: 1.54-5.55)], poor stress management [aOR 2.33 (95% CI: 1.04-3.88)], depression [aOR 5.17 (95% CI:1.63-8.26)], short sleep duration [aOR 2.72 (95% CI: 1.25-6.95)], physical inactivity [aOR 6.14 (95% CI: 1.41-9.22)], family history of T2DM [aOR 6.29 (95% CI: 2.61-9.27)], family history of hypertension [aOR 5.26 (95% CI: 2.18-8.91] were significant influential risk factors of Pre-DM/T2DM.
Conclusion
The most influential risk factor for the occurrence of early onset T2DM among young adults was family history of T2DM. Screening of family members of T2DM patients may lead to early intervention and reduced risk of subsequent complications.
Article Details
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References
International Diabetes Federation. IDF Diabetes Atlas 10th Edition; 2021.
Kementerian Kesehatan Republik Indonesia. Infodatin: tetap produktif, cegah, dan atasi diabetes melitus. Jakarta: Pusat Data dan Informasi Kementrian Kesehatan RI; 2020.
Rao G, Jensen ET. Type 2 diabetes in youth. Glob Ped Health 2020;7:1-9. doi: 10.177/2333794X20981343.
Bang KS, Jang SY, Choe JH. Factors affecting high-risk for diabetes among Korean adolescents: an analysis using the Eight Korea National Health and Nutrition Examination Survey. Children (Basel) 2022;9:1249. doi: https://doi.org/10.3390/children9081249.
Lascar N, Brown J, Pattison H, Barnett AH, Bailey CJ, Bellary S. Type 2 diabetes in adolescents and young adults. Lancet Diabetes Endocrinol 2018;6:69-80. doi: 10.1016/S2213- 8587(17)30186-9.
Saleh M, Kim JY, March C, Gebara N, Arslanian
S. Youth prediabetes and type 2 diabetes: Risk factors and prevalence of dysglycaemia. Ped Obese 2021;17:1-8. doi: https://doi.org/10.1111/jipo.12841.
Phan DH, Vu TT, Doan VT, Le TQ, Nguyen TD, Hoang MV. Assessment of the risk factors associated with type 2 diabetes mellitus: a national survey in Vietnam. Medicine 2022;104;1-3. doi: https://doi.org/10.1097%2FMD.0000000000031149.
Tanoey J, Becher H. Diabetes prevalence and risk factors of early-onset adult diabetes: results from the Indonesian family life survey. Glob Health Act 2021;14:2001144. doi: https://doi.org/10.1080/16549716.2021.2001144.
Yeh HC, Duncan BB, Schmidt MI, Wang NY, Brancati FL. Smoking, smoking cessation, and the risk for type 2 diabetes mellitus: a cohort study. Ann Intern Med 2010;152:1-10. doi: https://doi.org/10.7326/0003-4819-152-1- 201001050-00005.
Aravinda J. Risk factors in patients with type 2 diabetes in Bengaluru: A prospective study. World J Diabetes 2019;19:241-8. doi: https://doi.org/10.4239/wjd.v10.i4.241.
Akholkar PJ, Gandhi AA. Prevalence of obesity in diabetic and non-diabetic population. Int J Res Med Sci 2015;3:2114-7. DOI: http://dx.doi.org/10.18203/2320- 6012.ijrms20150336.
International Stress Management Association. Stress questionnaire; 2017.
Pfizer Inc. PHQ-9 patient depression questionnaire. PRIME-MD; 2005.
Perhimpunan Endokrinologi Indonesia (PERKENI). Pengelolaan dan Pencegahan Diabetes Mellitus Tipe 2 di Indonesia; 2021.
Xie J, Wang M, Long Z, et al. Global burden of type 2 diabetes in adolescents and young adults: systematic analysis of the Global Burden of Disease Study 2019. BMJ 2022;379. doi: https://doi.org/10.1136/bmj-2022-072385.
Wilmot E, Idris I. Early onset type 2 diabetes: risk factors, clinical impact and management. Ther Adv Chronic Dis 2014;5:234-44. doi: https://doi.org/10.1177/2040622314548679.
Gafarov V, Panov D, Gromova E, Gagulin I, Gafarova A. Psychosocial factors and the risk of type 2 diabetes mellitus in women population based epidemiological study. J Ger Med 2020;2:1-6. doi: https://doi.org/10.30564/jgm.v212.2304.
Yoshida Y, Wang J, Zu Y, Fonseca V, Jarvis FM. Rising prediabetes, undiagnosed diabetes, and risk factors in young women. Am J Prev Med 2023;64:423-27. doi: https://doi.org/10.1016/j.amepre.2022.10.001.
Htike ZZ, Webb D, Khunti K, Davies M. Emerging epidemic and challenges of type 2 diabetes in young adults. Diabet Manag 2015;5:473-83. doi: https://doi.org/10.2217/dmt.15.39.
Sliwinska-Mosson M, Milnerowisz H. The impact of smoking on the development of diabetes and its complications. Diab Vas Dis Res 2017;14:265-76. doi: https://doi.org/10.1177/1479164117701876.
Chan JCN, Lau ESH, Luk AOY, et al. Premature mortality and comorbidities in young-onset diabetes: a 7-year prospective analysis. Am J Med 2014;127:616-24. doi: 10.1016/j.amjmed.2014.03.018.
Magliano DJ, Sacre JW, Harding JL, Gregg EW, Zimmet PZ, Shaw JE. Young-onset type 2 diabetes mellitus - implications for morbidity and mortality. Nat Rev Endocrinol 2020;16:321-31. doi: 10.1038/s41574-020-0334-z.
Sattar N, Rawshani A, Franzen S, et al. Age at diagnosis of type 2 diabetes mellitus and associations with cardiovascular and mortality risks. Am Heart Assoc 2019;137:2228-37. doi: https://doi.org/10.1161/CIRCULATIONAHA.11 8.03788.
Strati M, Moustaki M, Psaltopoulou T, Vryonidou A, Paschou S. Early onset type 2 diabetes mellitus: an update. Endocrine 2024. doi: 10.1007/s12020-024-03772-w.
TODAY Study Group. Long-term complications in youth-onset type 2 diabetes. N Engl J Med 2021;385:416-26. doi: https://doi.org/10.1056/NEJMoa2100165.
Nanayakkara N, Curtis AJ, Heritier S, et al. Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses. Diabetologia 2021;64:275-87. doi: https://doi.org/10.1007/s00125-020-05319-w.
Huo L, Magliano DJ, Rancière F, et al. Impact of age at diagnosis and duration of type 2 diabetes on mortality in Australia 1997–2011. Diabetologia 2018;61:1055–1063. doi: https://doi.org/10.1007/s00125-018-4544-z.
Riaz BK, Selim S, Neo M, Karim MN, Zaman MM. Risk of depression among early onset type 2 diabetes mellitus patients. Dubai Diabetes Endocrinol J 2021;27:55–65. doi: https://doi.org/10.1159/000515683.