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Home humidity increased risk of tuberculosis in children living with adult active tuberculosis cases

Pudji Lestari, Florentina Sustini, Anang Endaryanto, Retno Asih
Submission date: Tuesday, 23 February 2016
Published date: Tuesday, 23 February 2016
DOI: http://dx.doi.org/10.18051/UnivMed.2011.v30.138-145

Abstract


Indonesia is one of the countries with the largest number of tuberculosis (TB) cases in the world. Environmental factors play significant roles in infection and disease development in children living with adult active TB cases. The aim of this study was to explore the environmental factors affecting TB risk in children, including humidity and number of people living in the same house with the children.  Using a cross-sectional study design, children living with active TB adults for at least 8 weeks were recruited. The subjects underwent clinical examination, tuberculin skin test (TST) and radiological investigations. Home visits were conducted three times daily, namely in the morning, at midday, and in the evening, to measure humidity by digital hygrometer and to observe home conditions. Of 56 index cases living with active TB adults in an urban low socio-economic setting, 64 contact TB children were recruited. These children were classified as class I with negative TST and no clinical signs, class II with positive TST and no clinical signs, and class III with both positive TST and clinical signs. There were 32 (50%) class I, 10 (15.6%) class II and 22 (34.3%) class III children. However, a sub-sample of 43 showed positive results for Mtb 16S rRNA, indicating that all children were infected. The humidity cut-off point was set at 75%, p=0.04 and EP 2.09 (CI= 1.32-3.29), signifying that children living in houses with a humidity higher than 75%, were twice more likely to be tuberculin positive. Environmental conditions playing a role in disease development were humidity and number of people living in the house.

Keywords


Tuberculosis; home condition; humidity; children

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References


Donald PR. Childhood tuberculosis: the hidden epidemic. Int J Tuberc Lung Dis 2004; 8:627-9.

Brent AJ, Anderson BST, Kampmanna B. Childhood tuberculosis: out of sight, out of mind? Trans R Soc Trop Med Hyg 2008;102: 217–8.

Lienhardt C, Sillah J, Fielding K, Donkor S, Mameh K, Warndoff, et al. Risk factor for tuberculosis infection in children in contact with tuberculosis cases in the Gambia, West Africa. Pediatrics 2003;111:e608-14.

World Health Organization. Global tuberculosis control: surveillance, planning and financing. WHO report 2007. Geneva: World Health Organization;2007.

Keman S. Kesehatan perumahan dan lingkungan pemukiman. J Kesehatan Lingkungan 2005;2;29-42

Laszlo A. for the International Union Against Tuberculosis and Lung Disease. Technical guide: sputum examination for tuberculosis by direct microscopy in low income countries. 5th ed. Paris: International Union Against Tuberculosis and Lung Disease;2000.

Ryan KJ. Sherris Medical microbiology. 4th ed. New York. McGraw Hill;2004.

Lillebaek T, Dirksen A, Baess I, Strunge B, Thomsen VO, Andersen AB, et al. Molecular evidence of endogenous reactivation of mycobacterium tuberculosis after 33 years of latent infection. J Infect Dis 2002;185:401–4.

Del Coral H, Paris SC, Marin ND, Marin DM, Lopez L, Henao HM, et al. IFN gamma response to Mycobacterium tuberculosis, risk of infection and disease in house hold contacts of tuberculosis patiens in Colombia. PloS One 2009;4:e 8257.

Lienhardt C, Fielding K, Hane AA, Niang A, Ndao CT, Karam F, et al. Evaluation of the prognostic value of IFN gamma release assays and tuberculin skin test in house hold contacs of infectious tuberculosis cases in Senegal. PloS One. 2010;5:e 10508.

Caley M, Flower T, Welch S. Risk of developing tuberculosis from a school contact: retrospective cohort study, United Kingdom, 2009. Euro Surveill 2010;15:19510.

Nguyen TH, Odermatt P, Slesak G, Barennes H. Risk of latent tuberculosis in children living in household with tuberculosis patiens: cross sectional survey in Northern Lao People’s Democratic Republic. BMJ Inf Dis 2009;9:96.

Elias D, Akuffo H, Britton S. Helminthes could influence the outcome of vaccines against TB in the tropic. Parasite Immunol 2006;28:507-13.

Alcais A, Fieschi C, Abel L, Casanova JL. Tuberculosis in children and adults: two distinct genetic diseases. J Exp Med 2005;19: 1617-21.

Shilova MV, Glumnaia TV. Influence of Seasonal and Environmental Factors on the Incidence of Tuberculosis. Prob Tuberk Bolezn Legk 2004;2: 17-22.

Nurhidayah I, Lukman M, Rakhmawati. Hubungan antara karakteristik lingkungan rumah dengan kejadian tuberculosis pada anak di Kecamatan Paseh Kabupaten Sumedang. Makalah Tuberculosis Bandung;2007.

Nursanti I. Faktor -faktor risiko terjadinya TB paru pada umur 15 tahun ke atas di Kota Jambi Prop NSI Jambi [thesis]. Semarang: Program Pasca Sarjana Universitas Diponegoro;2002.

Huttunen K, Hyvarinen A, Nevalainen A, Komulainen H, Hirvonen MR. Production of proinflamatory mediators by indoor bacterial and fungal spores in mouse and human cell line. Environ Health Perspec 2003;111:85-92.

Torvinen E, Meklin T, Torkko P, Suomalainen S, Reiman M, Katila ML, et al. Mycobacteria and fungi in moisture-damaged building materials. Appl Environ Microbiol 2006;72: 6822–4.

Sun Y, Zhang Y, Sundell J, Fan Z, Bao L. Dampness in dorm rooms and its association with allergy and airways iInfection among college students in China: a cross sectional study. Indoor Air 2009;19:348-56.

Olender S, Saito M, Apgar J, Gillenwater K, Bautista CT, Lescano AG, et al. Low prevalence and increased household clustering of Mycobacterium tuberculosis infection in high altitude villages in Peru. Am J Trop Med Hyg 2003;68:721-7.

Vree M, Hoa NB, Sy DN, Co NV, Cobelen FG, Borgdoff MW. Low tuberculosis notification in mountainous Vietnam is not due to low case detection: a cross-sectional survey. BMC Infect Dis 2007;19:109.

Rahajoe NN, Basir D, MS Makmuri, Kartasasmita CB, editors. Pedoman nasional tuberkulosis anak. Edisi Kedua. Jakarta: Unit Kerja Koordinasi Respirologi Ikatan Dokter Anak Indonesia;2008.


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