Does vitamin E play a role in the primary prevention of stroke?

Article Sidebar

PDF
Published: Apr 23, 2011
DOI: https://doi.org/10.18051/UnivMed.2011.v30.1-2 Universa Medicina
Abstract Viewed: 270
PDF Downloaded: 124

Main Article Content

Adi Hidayat
Department of Community Medicine Medical Faculty, Trisakti University

Abstract

A few decades ago it was generally accepted from experimental studies, animal experiments, and epidemiological cohort studies that atherogenesis is linked to oxidative stress and that antioxidant supplementation, notably vitamin E supplementation, is associated with a low incidence of cardiovascular disease (CVD). This view led to the widespread use of vitamin E and other antioxidants for reducing CVD morbidity and mortality. In vitro and animal studies on antioxidant and anti-inflammatory properties of alpha- and gamma-tocopherols also found that these antioxidants had anti-inflammatory properties.

Article Details

How to Cite
Hidayat, A. (2011). Does vitamin E play a role in the primary prevention of stroke?. Universa Medicina, 30(1), 1–2. https://doi.org/10.18051/UnivMed.2011.v30.1-2
Issue
Vol. 30 No. 1 (2011)
Section
Review Article

The journal allows the authors to hold the copyright without restrictions and allow the authors to retain publishing rights without restrictions.

References

Jiang Q, Ames BN. Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB J 2003;17:816–22.

Singh U, Jialal I. Anti-inflammatory effects of alpha-tocopherol. Ann N Y Acad Sci 2004;1031:195–203.

Young IS, Woodside JV. Antioxidants in health and disease. J Clin Pathol 2001;54:176–86.

Cook NR, Albert CM, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, et al. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women’s Antioxidant Cardiovascular Study. Arch Intern Med 2007;167:1610-8.

Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:37-46.

Dotan Y, Pinchuk I, Lichtenberg D, Leshno M. Decision analysis supports the paradigm that indiscriminate supplementation of vitamin E does more harm than good. Arterioscler Thromb Vasc Biol 2009;29:1304-9.

Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet 2008;371:1612-23.

Schürks M, Glynn RJ, Rist PM, Tzourio C, Kurth T.Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ 2010;341:c5702 doi:10.1136/bmj.c5702.