Soyfood consumption and risk of glycosuria in post-menopausal women

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Nurmillah Nurmillah
Irena Stafani Yolantha
Victor Livinus


Menopause is a natural event to be experienced by every woman and appears to be associated with increased risk for developing type 2 diabetes mellitus. It has been postulated that a diet high in legumes may be beneficial for the prevention of glycosuria. These unique components of soy have been shown to have beneficial effects on glucose and insulin homeostasis. The objective of the present study was to examine the possibility of an association between soy food consumption and risk of glycosuria in postmenopausal women. A cross-sectional study was conducted among 94 postmenopausal women attending Mampang Prapatan Health Center, Mampang Prapatan subdistrict, South Jakarta. Anthropometric measurements were taken using standard instruments and dietary intake was assessed with a validated food-frequency questionnaire. A dipstick semiquantitative assay for urinary glucose was used to define glycosuria (positive). The results showed that 12.8% of postmenopausal women had glycosuria and mean isoflavone intake was 69.5 ± 61.4 g/d. Intake of isoflavone was inversely associated with risk of glycosuria. Compared to women in the lowest quintile of isoflavone intake (Q1), postmenopausal women in the highest quintile (Q5) had a lower risk for glycosuria of 0.30 times that of Q1, which risk was however statistically not significant (OR = 0.30; 95% CI = 0.02 – 3.14). In conclusion, isoflavone may play a role in the prevention of glycosuria (an important indicator of diabetes) among postmenopausal women.

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Nurmillah, N., Yolantha, I. S., & Livinus, V. (2016). Soyfood consumption and risk of glycosuria in post-menopausal women. Universa Medicina, 29(3), 162–168.
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Zimmet P. Globalization, coca-colonization and the chronic disease epidemic: can the doomsday scenario be averted? J Intern Med 2000;247:301–10.

Henderson V. Isoflavones: food for thoughtful consideration. Menopause 2003;10: 189-90.

Branca F, Lorezentti S. Health effects of phytoestrogens. Forum Nutr 2005;57:100-11.

Somekawa Y, Chiguchi M, Ishibashi T, Aso T. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol 2001;97:109-15.

Chester EA. Soy for cardiovascular indications. Am J Health Syst Pharm 2001;58: 663–6.

Lavigne C, Marette A, Jacques H. Cod and soy proteins compared with casein improve glucose tolerance and insulin sensitivity in rats. Am J Physiol Endocrinol Metab 2000;278:491–500.

Hermansen K, Sondergaard M, Hoie L, Carstensen M, Brock B. Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects. Diabetes Care 2001;24:228–33.

Jayagopal V, Albertazzi P, Kilpatrick ES, Howarth EM, Jennings PE, Hepburn DA, et al. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care 2002;25:1709–14.

Goodman-Gruen D, Kritz-Silverstein D. Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr 2001;131: 1202-6.

Foster-Powell K, Holt SH, Brand-Miller JC. International table of glycemic index and glycemic load values. Am J Clin Nutr 2002;76:5-56.

Zhou BF. Cooperative meta-analysis group of the working group on obesity in China. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults: study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci 2002;15:83-96.

Fred Hutchinson Cancer Research Center. Soy food questionnaire;2002. Available at: Accessed December 12, 2009.

Nutrient Data Laboratory Beltsville Human Nutrition Research Center Agricultural Research Service U.S. Department of Agriculture. USDA. Database for the isoflavone content of selected foods. Release 2.0. Baltimore: U.S. Department of Agriculture Agricultural Research Service; 2008.

Bartlett JE II, Kotrlik JW, Higgins CC. Organizational research: determining appropriate sample size in survey research. Info Technol Learn Perform J 2001;19:43-50.

Nagata C, Takatsuka N, Shimizu H. Soy and fish oil intake and mortality in a Japanese community. Am J Epidemiol 2002;156:824-31.

Lavigne C, Marette A, Jacques H. Cod and soy proteins compared with casein improve glucose tolerance and insulin sensitivity in rats. Am J Physiol Endocrinol Metab 2000;278:491-500.

Villegas R, Gao YT, Yang G, Li HL, Elasy TA, Zheng W, et al. Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women’s Health Study. Am J Clin Nutr 2008;87: 162-7.

Bhathena SJ, Velasquez MT. Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr 2002;76;1191-201.

Goodman-Gruen D, Kritz-Silverstein D. Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr 2001; 131:1202-6.

Pino AM, Valladares LE, Palma MA, Mancilla AM, Yanez M, Albala C. Dietary isoflavones affect sex hormone-binding globulin levels in postmenopausal women. J Clin Endocrinol Metab 2000;85:2797-800.

Ho SC, Chen YM, Ho SSS, Woo JLF. Soy isoflavone supplementation and fasting serum glucose and lipid profile among postmenopausal Chinese women: a double-blind, randomized, placebo-controlled trial. Menopause 2007;14: 905-12.

Liu ZM, Chen YM, Ho SC, Ho YP, Woo J. Effects of soy protein and isoflavones on glycemic control and insulin sensitivity: a 6-mo double-blind, randomized, placebo-controlled trial in postmenopausal Chinese women with prediabetes or untreated early diabetes. Am J Clin Nutr 2010;91:1394-401.

Morito K, Hirose T, Kinjo J, Hirakawa T, Okawa M, Nohara T ,et al. Interaction of phytoestrogens with estrogen receptors alpha and beta. Biol Pharm Bull 2001; 24:351-6.

Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, Saville B, et al. Toxicology of environmental estrogens. Reprod Fertil Dev 2001;13:307-15.

Mueller SO, Simon S, Chae K, Metzler M, Korach KS. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and beta (ERbeta) in human cells. Toxicol Sci 2004;80:14–25.

Glazier MG, Bowman MA. A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med 2001;161:1161-72.

Fung TT, Willett WC, Stampfer MJ, Manson JE, Hu FB. Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med 2001; 161:1857-62.

van Dam RM, Rimm EB, Willett WC, Stampfer MJ, Hu FB. Dietary patterns and risk for type 2 diabetes mellitus in U.S. men. Ann Intern Med 2002;136:201-9.

Heidemann C, Hoffmann K, Spranger J, Klipstein-Grobusch K, Möhlig M, Pfeiffer AF, et al. A dietary pattern protective against type 2 diabetes in the European prospective investigation into cancer and nutrition (EPIC)–potsdam study cohort. Diabetologia 2005;48:1126-34.

Chaturvedi S, Jain N, Bhatia A. Evaluation of semi-quantitative methods for protein and sugar estimation in urine. Indian J Pathol Microbiol 2001;44:399-401.