Quercetin reduce cardiomyocytes damage in type 2 diabetic rats
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Abstract
Diabetes mellitus (DM) is a group of metabolic diseases which are characterized by hyperglycemia, resulting in various complications. A major macrovascular complication of DM is cardiac failure due to cardiomyopathy. Hyperglycemia
increases oxidative stress, so an oxidative-stress reducing therapeutic agent is required, e.g. the antioxidant quercetin. The aim of this study was to assess the effects of quercetin in reducing damage to cardiomyocytes of type 2 diabetic rats.
METHODS
This research is an experimental study using 40 rats. With simple random
allocation, rats were divided into eight groups, then type 2 diabetes mellitus
was induced using streptozotocin (5 rats per group). The test material was
quercetin given at doses of 5, 20 and 80 mg/kgBW/day orally for 4 weeks.
Each single dose of quercetin was given in combination with glibenclamide 5
mg/ kgBW/day. After 4 weeks the rats were decapitated and the cardiac tissues
taken to quantify the percentage of cell damage after hematoxylin-eosin staining
(HE).
RESULTS
Quercetin at a dose of 80 mg/kgBW/day can lower cardiomyocyte damage
better than quercetin at doses of 5 or 20 mg/kgBW/day. A combination of
quercetin and glibenclamide can significantly lower levels of cardiomyocyte
damage better than quercetin without glibenclamide (p<0.05).
CONCLUSION
Quercetin at a dose of 80 mg/kgBW/day with or without glibenclamide can
lower damage to cardiomyocytes of type 2 diabetic rats. Thus quercetin might
serve as a valuable protective agent in cardiovascular inflammatory diseases
in diabetic rats.
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