Epidemiology of osteoporosis in postmenopausal women aged 47 to 60 years

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Meiyanti Meiyanti


Osteoporosis is a disorder having the characteristic features of low bone mass and structural degeneration. There are several factors affecting the prevalence of osteoporosis in postmenopausal women, such as age, age at menarche, duration of menopause, dietary or nutritional intakes, life style and level formal education. In connection with the increasing global prevalence of osteoporotic fractures, the purpose of the present study was to determine the prevalence and the influencing factors of osteoporosis in postmenopausal women. A cross-sectional study, involving 203 postmenopausal women aged 47-60 years, was conducted in 4 villages of Mampang Prapatan subdistrict, from February to April 2010. Bone mineral density (BMD) of lumbar spine 1-4, femoral neck, and left radius was measured by dual-energy X-ray absorptiometry (Lunar DPX Bravo Nomusa densitometer, GE Medical Systems) at Budi Jaya Hospital, Jakarta. The T-score threshold, defined as £ -2.5 was used to identify subjects with osteoporosis The results of the study showed that the highest prevalence of osteopenia of 45.8% was found in the femoral neck, while the highest prevalence of osteoporosis of 30% was found in the distal radius. Age, duration of menopause, and number of pregnancies yielded a significant correlation with BMD of the lumbar vertebrae and the distal radius. Body mass index (BMI) was also significantly correlated with BMD of lumbar vertebrae, femoral neck and distal radius. Effective strategies for the prevention and management of osteopenia and osteoporosis are needed.

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How to Cite
Meiyanti, M. (2016). Epidemiology of osteoporosis in postmenopausal women aged 47 to 60 years. Universa Medicina, 29(3), 169–176. https://doi.org/10.18051/UnivMed.2010.v29.169-176
Review Article


Häussler B, Gothe H, Göl D, Glaeske G, Pientka L, Felsenberg D. Epidemiology, treatment and costs of osteoporosis in Germany-the BoneEva Study.Osteoporos Int 2006;18:77-84.

Zhai G, Hart DJ, Valdes AM, Kato BS, Richards HB, Hakim A, et al. Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow up population based study. Osteoporos Int 2008;19:1211-7.

National Institutes of Health Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA 2001;285:785-95.

Brown SE. Osteoporosis: snap, crackle and pop some pills. Northeast Florida Med 2006;57:14-20.

World Health Organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Geneva: WHO technical report series 843;1994.

Johnson NK, Clifford T, Smith KM. Understanding risk factors, screening and treatment of postmenopausal osteoporosis. Orthopedics 2008;31:676-80.

Pietschmann P, Rauner M, Sipos W, Schindl KK. Osteoporosis: an age related and gender specific disease a mini review. Gerontology 2009;55:3-12.

World Health Organization. Appropiate body mass index for Asian populations and its implication for policy and intervention strategies. The Lancet 2004;363:157-63.

Limpaphayom KK, Taechakraichana N, Jaisamrarn U, Bunyavejchevin S, Chaikittisilpa S, Poshyachinda M, et al. Prevalence of osteopenia and osteoporosis in Thai women. Menopause 2001;8:65-9.

Puslitbang Gizi Depkes. Osteoporosis. Available at: http://www.pppl.depkes.go.id. Accessed September 2, 2010.

Mawie M. Serum estradiol level and bone mineral density in postmenopausal women. Univ Med 2010;29:90-5.

Finkelstein JS. Osteoporosis. In: Goldman L, Auseillo N, editors. Cecil Textbook of Medicine. 22nd ed. Philadelphia: Saunders;2004. p.1547-55.

Finkelstein JS, Brockwell SE, Mehta V, Greengale GA, Sowers MR, Ettinger B. Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab 2008;93:861-8.

Sakondhavat C, Thangwijitra S, Soontrapa S, Kaewrudee S, Somboonporn W. Prevalence of osteoporosis in postmenopausal women at Srinagarind Hospital, Khon Kaen University. Srinagarind Med J 2009;24:113-0.

Liu-Ambrose T, Kravetsky L, Bailey D. Change in lean body mass is a major determinant of change in areal bone mineral density of proximal femur: a 12 year observational study. Calcif Tissue Int 2006;79:145-51.

Uusi K, Sievanen H, Pasanen M, Kannus P. Age-related decline in trabecular and cortical density: a 5 year peripheral quantitative computed tomography follow up study of pre- and postmenopausal women. Calcif Tissue Int 2007; 81:249-53.

Khosla S, Melton LJ, Achenbach SJ, Oberg AL, Riggs BL. Hormonal and biochemical determinants of trabecular microstructure at the ultradistal radius in women and men. J Clin Endocrinol Metab 2006;91:885-91.

Finkelstein JS, Lee ML, Sowers M, Ettinger B, Neer RM, Kelsey JL, et al. Ethnic varation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and life style factors. J Clin Endocrinol Metab 2002;87:3057-67.

Li HL, Han MZ. Menarche and menopause, age, factors such a postmenopausal osteoporosis and the incidence of relationship. Chinese J Gynaecol Obstet 2005;12;796-98.

Felson DT, Zhang Y, Hannan MT, Anderson JJ. Effects of weight and body mass index on bone mineral density in men and women: The Framingham Study. J Bone Miner Res 2003;8: 567-73.

Livshits G, Pantsulaia IA, Trofimov S, Kobyliansky E. Genetic variation of circulating leptin is involved in genetic variation of hand bone size and geometry. Osteoporos Int 2003;14:476-83.

Thomas T, Burguera B. Is leptin the link between fat and bone mass? J Bone Miner Res 2002;17: 1563-69.

Sukumar D, Schlussel Y, Riedt S, Gordon C, Stahl T, Shapses A. Obesity alters cortical and trabecular bone density and geometry in women. Osteoporos Int 2010;22:634-45.

O’Brien KO, Nathanson MS, Macini J, Witter FR. Calsium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period. Am J Clin Nutr 2003;78:1188-93.

O’Brien KO, Donangelo CM, Zapata CL, Abrams SA, Spencer EM, King J. Bone calcium turnover during pregnancy and lactation in womwn with low calcium diets is associated with calcium intake and circulating insulin-like growth factor I concentrations. Am J Clin Nutr 2006;83:317-23.

Cure-Cure C, Cure-Ramirez P, Teran E, Lopez-Jaramillo P. Bone mass peak in multiparity and reduced risk of bone fractures in menopause. Int J Gynaecol Obstet 2002;76:285-91.

Streeten EA, Ryan KA, Mc Bride DJ, Pollin TI, Shuldiner AR, Mitchell BD. The relationship between parity and bone mineral density in women characterized by a homogeneous lifestyle and high parity. J Clin Endocrinol Metab 2005; 90:4536-41.

Lenora J, Lekamwasan S, Karlsson M. Effects of multiparity and prolonged breast-feeding on maternal bone mineral density: a community-based cross-sectional study. BMC Womens Health 2009;9:19.

Deng FY, Lei SF, Li MX, Jiang C, Dvornyk V, Deng HW. Genetic determination and correlation of body mass index and bone mineral density at the spine and hip in Chinese Han ethnicity. Osteoporos Int 2006;17:119-24.

Lazcano-Ponce E, Tamayo J, Diaz R, Burguete AI, Salmeron J. Correlation trends for bone mineral density in Mexican women: evidence of familiar predisposition. Salud Publica de Mexico 2009;51Suppl 1:S93-9.

Ho SC, Chen YM, Woo JLF. Educational level and osteoporosis risk in postmenopausal women. Am J Epidemiol 2005;161:680-90.