Duration of asthma affects pulmonary function in asthmatic children

Main Article Content

Ellen P. Gandaputra


Asthma is a common chronic disease and information on its management practices at the community level is helpful in identifying problems and improving asthma care. The prevalence of asthma in children below 18 years of age is around 9.3% and is on the increase. The aim of the present study was to determine the relationship between pulmonary function and duration of asthma in children. This was a cross-sectional study conducted at the outpatient clinic of RSUPN dr. Cipto Mangunkusumo in Central Jakarta. The study subjects were children aged 6-18 years with frequent episodic or persistent asthma. Among the 31 subjects there were 28 children with frequent episodic asthma and 3 children with persistent asthma. The duration of frequent episodic asthma ranged from 4 to 84 months, with a mean duration of 28 months. The FEV1 and V50 values decreased in proportion to the duration of asthma (p=0.003 and p=0.012, respectively). Mean FEV1 in persistent asthma was lower than that in frequent episodic asthma (82.7% vs. 61.2% at p=0.005). Similarly V50 and V25 were lower in persistent asthma, but the decrease was not statistically significant. The decrease in FEV1 and V50 values was proportional to the duration of asthma. The severity of asthma is indicative of inadequate asthma control, resulting in a proportional decrease in pulmonary function. Therefore prevention of asthmatic attacks is an essential feature of asthma management in children in order to enhance their quality of life.

Article Details

How to Cite
Gandaputra, E. P. (2010). Duration of asthma affects pulmonary function in asthmatic children. Universa Medicina, 29(1), 1–7. https://doi.org/10.18051/UnivMed.2010.v29.1-7
Review Article


Bisgaard H, Szefler S. Prevalence of asthma-like symptoms in young children. Pediatr Pulmonol 2007;42:723-8.

Kurukulaaratchy RJ, Fenn MH, Waterhouse LM, Matthews SM, Holgate ST, Arshad SH. Characterization of wheezing phenotypes in the first 10 years of life. Clin Exp Allergy 2003;33: 573-8.

Kling S, Gie R, Goussard P. Inhaled corticosteroids in childhood asthma. Curr Allergy Clin Immunol 2003;16:8-10.

Terr AI. The atopic diseases. In: Parslow TG, Stites DP, Terr AI, Imboden JB, editors. Medical immunology. 10th ed. Boston: McGraw Hill;2003. p.349-69.

Savichi G, Dovey M. Chronic childhood asthma: definition, epidemiology, and pathophysiology. Available at : http://www.uptodate.com. Accessed November 11,2009.

Beasley R, Keil U, von Mutius E on behalf of the ISAAC Steering Committee. Worldwide variation in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis and atopic eczema: the international study of asthma and allergies in childhood (ISAAC). Lancet 1998;351:1225–32.

Beasley R, Ellwood P, Asher I. International patterns of the prevalence of pediatric asthma: The ISAAC program. Pediatr Clin N Am 2003; 50:539–53.

UKK Pulmonologi. Pedoman nasional asma anak. Dalam: Rahajoe N, Supriyatno B, Setyanto DB, penyunting. Jakarta: PP IDAI;2004.h.1-44.

Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma, from bronchoconstriction to airways inflammation and remodeling. Am J Respir Cri Care Med 2000;161:1720-45.

Payne DNR, Rogers AV, Adelroth E, Bandi V, Guntupalli KK, Bush A, et al. Early thickening of the reticular membrane in children with difficult asthma. Am J Respir Crit Care Med 2003;167: 78-82.

von Mutius E. Environmental factors influencing the development and progression of pediatric asthma. J Allergy Clin Immunol 2002;109:S525–32.

Weinmay G, Weiland SK, Bjo¨rkste´n B, Brunekreef B, Bu¨chele G, Cookson WOC, et al. Atopic sensitization and the international variation of asthma symptom prevalence in children. Am J Respir Crit Care Med 2007; 176:565–74.

Scrivener S, Yemaneberhan H, Zebenigus M, Tilahun D, Girma S, Ali S, et al. Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study. Lancet 2001;358:1493–9.

Palmer LJ, Celedon JC, Weiss ST, Wang B, Fang Z, Xu X. Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China. Am J Respir Crit Care Med 2002;165:1489–93.

Kaswandani N. Uji fungsi paru pada batuk kronik. Dalam: Trihono PP, Kurniati N, penyunting. Strategi pendekatan klinis secara professional batuk pada anak. Jakarta: Departemen Ilmu Kesehatan Anak FKUI-RSCM;2006. h.26-39.

Ko FWS, Wang HY, Wong GW, Leungz TF, Hui DSC, Chan DPS, et al. Wheezing in Chinese schoolchildren: disease severity distribution and management practices, a community-based study in Hong Kong and Guangzhou. Clin Exp Allergy 2005;35:1449–56.

Tehuteru ES. Profile of lung function test in pediatric asthma patients. Univ Med 2003;22:1-4.

Joseph-Bowen J, de Klerk NH, Firth MJ, Kendall GE, Holt PG, Sly PD. Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children. Am J Respir Crit Care 2004;169:850-4.

Bacharier LB, Strunk RC, Mauger D, White D, Lemanske RF, Sorkness CA. Classifying asthma severity in children. Am J Respir Crit Care Med 2004;170:426-32.

Zeiger RS, Dawson C, Weiss S. Relationships between duration of asthma and asthma severity among children in the Childhood Asthma Management Program (CAMP). J Allergy Clin Immuno 1999;103:376-87.

Apostol GG, Jacobs DR, Tsai AW, Crow RS, Williams OD, Townsend MD, et al. Early life factors contribute to the decrease in lung function between ages 18 and 40: the coronary artery risk development in young dults study. Am J Respir Crit Care Med 2002;166:166–72.

Covar RA, Spahn JD, Murphy JR, Szefler SJ, for the Childhood Asthma Management Program Research Group. Progression of asthma measured by lung function in the childhood asthma management program. Am J Respir Crit Care Med 2004;170:234–41.

Mauad T, Bel EH, Sterk PJ. Asthma therapy and airway remodeling. J Allergy Clin Immunol 2007;120:997-1009.

Reddel HK, Belousova EG, Marks GB, Jenkins C. Does continuous use of inhaled corticosteroids improve outcomes in mild asthma? A double-blind randomized controlled trial. Primary Care Respiratory J 2008;17:39-45.

Ramsdell JQ, Nayak AS, Bensch GW. Efficacy of treatment with once-daily evening dosing of mometasone furoate dry powder inhaler 200 micrograms in asthma stratified by baseline severity. Am J Respir Crit Care Med 2009;179: 19-24.