Multimicronutrient supplementation and asymptomatic urinary tract infections in the elderly

Article Sidebar

PDF
Published: Feb 26, 2016
DOI: https://doi.org/10.18051/UnivMed.2009.v28.25-33 Universa Medicina
Abstract Viewed: 427
PDF Downloaded: 95
Keywords:
Multimicronutrients urinary tract infection resistance elderly

Main Article Content

Paul Boekitwetan
Department of Microbiology, Medical Faculty, Trisakti University
Julius E. Surjawidjaja
Department of Microbiology, Medical Faculty, Trisakti University
Mahyunis Aidilfit
Department of Microbiology, Medical Faculty, Trisakti University
Murad Lesmana
Department of Microbiology, Medical Faculty, Trisakti University

Abstract

As human life expectancy continues to increase, developing countries are reporting higher percentages of elderly in their respective populations. The defense mechanisms of the elderly are reduced due to several factors, such as increased susceptibility to infection, specifically urinary tract infection (UTI). A randomised, placebo-controlled, double-blind trial was conducted to assess whether multimicronutrient supplementation is effective in reducing UTIs in older people in the community. A total of 261 elderly who lived in Mampang Prapatan district, South Jakarta, were randomised to daily multimicronutrient supplementation or control groups. The primary outcomes were the incidence of asymptomatic UTI, the organisms responsible for UTIs and the results of sensitivity tests on UTI microorganisms. UTI was defined as culture-positive urine yielding a single species of organisms in numbers greater than 104 cfu/mL urine specimen. At base-line 19.5% of the elderly had UTI, namely 23.7% patients in the MMN group and 16.7% in the control group, but the difference was not statistically significant (p=0.158). Escherichia coli was the most common microorganism, isolated in 20.7% of the MMN group and 17.5% of the control group. After six months of supplementation, UTI in the MMN group decreased by 40.6% compared with only 14.4% in the control group. The numbers of E. coli also declined by 64.3% in the MMN group compared to 37.8% in the control group. This study has confirmed the beneficial effect of multimicronutrient supplementation on UTI in the elderly.

Article Details

How to Cite
Boekitwetan, P., Surjawidjaja, J. E., Aidilfit, M., & Lesmana, M. (2016). Multimicronutrient supplementation and asymptomatic urinary tract infections in the elderly. Universa Medicina, 28(1), 25–33. https://doi.org/10.18051/UnivMed.2009.v28.25-33
Issue
Vol. 28 No. 1 (2009)
Section
Review Article

The journal allows the authors to hold the copyright without restrictions and allow the authors to retain publishing rights without restrictions.

References

Badan Koordinasi Keluarga Berencana Nasional [National Coordinating Board of Family Planning]. Data Keluarga penduduk Indonesia. Jakarta: Badan Koordinasi Keluarga Berencana Nasional. 2004. Available at: http://www.bkkbn.go.id. Accessed August 10, 2008.

United Nations. World population aging 1950-2050. New York: United Nations; 2001. Available at http://www.un.org/esa/population/publications/worldageing19502050/pdf/preface_web.pdf. Accessed August 12, 2008.

High KP. Nutritional strategies to boost immunity and prevent infection in elderly individuals. Clin Infect Dis 2001;33:1892-900.

Castle SC. Clinical relevance of age-related immune dysfunction. Clin Infect Dis 2000;31:578–85.

Achmad IA, Birowo P. Profil pasien infeksi saluran kemih usia lanjut di Rumah Sakit Cipto Mangunkusumo Jakarta [Profile of urinary tract infection in elderly patients]. Maj Kedokter Indon 2006;56:114-7.

Mcmurdo ET, Bissett LY, Price RJG, Phillips G, Crombie IK. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 2005;34:256–61.

Williams ME. Treatment of UTI in an elderly male. Medscape Fam Med 2002;4:2-6.

Trotter CL, Stuart JM, George R. Increasing hospital admissions for pneumonia, England. Emerg Infect Dis 2008;14:727–33.

Lutters M, Vogt-Ferrier NB. Antibiotic duration for treating uncomplicated, symptomatic lower urinary tract infections in elderly women. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD001535. DOI: 10.1002/14651858. CD001535. pub2.

Thomson RB, Miller JM. Specimen collection, transport, and processing: bacteriology In: Murray P, Baron EJ, Jorgensen Jh, Pfaller MA, Yolken RH, editors. Manual of clinical Microbiology. 8th ed. Washington DC: ASM Press; 2003.p.286-330.

Noviana H. Antibiotic susceptibility of Escherichia coli isolated from various clinical specimens. J Kedokter Trisakti 2004;23:122-6.

Adedipe A, Lowenstein R. Infectious emergencies in the elderly. Emerg Med Clin N Am 2006;24:433-48.

Ginde AA, Rhee SH, Katz ED. Predictors in outcome in geriatric patients with urinary tract infections. J Emerg Med 2004;27:101–8.

Shortliffe LDM, McCue JD. Urinary tract infections at the age extremes: pediatrics and geriatrics. Am J Med 2002;113:55S–66S.

Bucher A, Sorkness N, Lundqvist K, Ronning K. Infection and use of antibiotics in nursing home. Tidsskr Nor Laegeforen 2001;121:827–30.

Nowroozi J, Mirgalili AS, Bagheri KP. Study on nutrition status and urinary tract infection in elderly people at nursing home. Iranian J Publ Health 2004; 33:36-9.

Nicole LE. Urinary tract infection in long-term facility residents. Clin Infect Dis 2000;31:757-61.

Rao GG, Patel M. Urinary tract infection in hospitalized elderly patients in the United Kingdom: the importance of making an accurate diagnosis in the post broad-spectrum antibiotic era. J Antimicrob Chemother 2009;63:5–6.

High KP. Nutritional strategies to boost immunity and prevent infection in elderly individuals. Clin Infect Dis 2001;33:1892–900.

Barringer TA, Kirk JK, Santaniello AC, Foley KL, Michielutte R. Effect of a multivitamin and mineral supplement on infection and quality of life. Ann Int Med 2003;138:365-71.

Prentice AM, Ghattas H, Cox SE. Host-pathogen interactions: can micronutrient tip the balance?. J Nutr 2007;137:1334-7.