Main Article Content
Intractable epilepsy considerably affects both the private and social life of the patient. The objective of this study was to determine the quality of life of intractable epileptic adolescents and its correlated factors.
A cross sectional study was conducted in the Pediatric Neurology outpatient clinic of Dr. Soetomo Hospital. All intractable epileptic adolescents aged between 10 to 16 years were asked to complete a questionnaire on quality of life in epilepsy for adolescents (QOLIE-AD-48). A multiple linear regression was used to analyze the data through SPSS v17.0.
Thirty one patients with mean age of 12.41 ± 1.40 years were enrolled in the study. The mean duration of diagnosed intractable epilepsy was 6.12 ± 4.30 years. Mean score for impact of epilepsy was 57.11 ± 24.50, for memory and concentration 53.54 ± 26.66, physical functioning 65.56 ± 23.67, social stigma 52.23 ± 17.48, social support 52.64 ± 22.69, behavior at school 57.51 ± 26.50, attitude 53.40 ± 16.70 and health perception 61.51 ± 11.30. Multiple linear regression results showed that quality of life (QOL) was not significantly correlated with duration of epilepsy, sex and nutritional status (p>0.05), but increasing age was significantly decreases quality of life (p<0.05).
Intractable epileptic adolescents have higher scores for physical functioning and health perception, but lower scores for social stigmatization. Social support has extremely low scores. Increasing age decreases quality of life in adolescents with intractable epilepsy.
Sinha S, Siddiqui KA. Definition of intractable epilepsy. Neurosciences 2011;16:3-6.
Lach LM, Ronen GM, Rosenbaum PL, et al. Health-related quality of life in youth with epilepsy: theoretical model for clinicians and researchers. Part I: The role of epilepsy and co-morbidity. Qual Life Res 2006;15:1161-71.
Zashikhina A, Hagglof B. Health-related quality of life in adolescents with chronic physical illness in northern Russia: a cross-sectional study. Health Qual Life Outcomes 2014;12:12.
Waters E, Davis E, Ronen GM, et al. Quality of life instruments for children and adolescents with neurodisabilities: how to choose the appropriate instrument. Dev Med Child Neurol 2009;51:660-9. DOI: 10.1111/j.1469-8749.2009.03324.x.
Cramer J, Westbrook LE, Perrine K, et al. Development of the quality of life in epilepsy inventory for adolescents: the QOLIE-AD-48. Epilepsia 1999;40:1114-21.
Malhi P, Singhi P. Correlates of quality of life with epilepsy. Indian J Pediatr 2005;72:131-5.
Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies. Epilepsia 2010;51:1069-77.
Sabaz M, Cairns DR, Lawson JA, et al. The health-related quality of life of children with refractory epilepsy: a comparison of those with and without intellectual disability. Epilepsia 2001;42:621-8.
Monir ZM, El-Alameey IR, Eltahlawy E. Health related quality of life of children with epilepsy in Egypt. J Arab Soc Med Res 2013;8:53-66.
Modi AC, Ingerski LM, Rausch JR, et al. Treatment factors affecting longitudinal quality of life in new onset pediatric epilepsy. J Pediatr Psychol 2011;36:466-75.
Eddy CM, Rickards HE, Cavanna AE. The cognitive impact of antiepileptic drugs. Ther Adv Neurol Disard 2011;4:385-407.
Hessen E, Lossius MI, Reinvang I, et al. Influence of major antiepileptic drugs on attention, reaction time and speed of information processing: result from a randomized, double-blind, placebo-controlled withdrawal study of seizure-free epilepsy patients receiving monotherapy. Epilepsia 2006;47:2038-45.
Aydemir N, Ozkara C, Unsal P. A comparative study of health related quality of life, psychological well-being, impact of illness and stigma in epilepsy and migraine. Seizure 2011; 20:679-85.
Siqueira NF, Guerreiro MM, Pedroso de Souza EA. Self-esteem, social support perception and seizure controllability perception in adolescents with epilepsy. Arq Neuropsiquiatr 2011;69:770-4.
Taylor J, Jacoby A, Baker GA, et al. Self-reported and parent-reported quality of life of children and adolescents with new-onset epilepsy. Epilepsia 2011;52:1498-98.
Shakir M, Al-Asadi J. Quality of life and its determinants in people with epilepsy in Basrah, Iraq. SQU Medical Journal 2012;12:449-57.
Ohaeri JU, Awadalla AW, Farah AA. Quality of life in people with epilepsy and their family caregivers: An Arab experience using the short version of WHO Quality of Life Instrument. Sustech 2009;30:1-22.
Kerr C, Nixon A, Angalakuditi M. The impact of epilepsy on children and adult patients’ lives: development of a conceptual model from qualitative literature. Seizure 2011;20:764-74.
Sharoni SK, Rahman JA, Jamaludin MA, Radzi NM. HRQOL among children with epilepsy. International J Undergraduates Study 2013;2:19-25.
Aggarwal A, Datta V, Thakur LC. Quality of life in children with epilepsy. Indian Pediatrics 2011; 48:893-6.