The role of tea in cardiovascular disease

Main Article Content

Fajar Arifin Gunawijaya

Abstract

Tea is an infusion of the leaves of the Camellia sinensis plant, which is not to be confused with so-called ‘herbal’ teas. Some biologically active chemicals in tea include flavonoids, caffeine and fluoride. For as long as people have been drinking tea, there have been health benefits associated with it. However, it has only been within the past 20 to 30 years that scientific studies have been conducted to investigate the validity of these claims. Many animal studies, and recently an increasing number of human studies, including epidemiological studies and clinical trials, have examined the relationship between tea drinking and health. Overall, observational studies in humans suggest that daily consumption of at least 3 cups of tea may be associated with a risk reduction of mortality (44%) after myocardial infarction compared with non-tea drinkers. The possibility that tea consumption reduces the risk of cardiovascular events remains open to the need for further clinical trials to clarify the effects of tea polyphenols in humans in order to recommend their use against cardiovascular diseases.

Article Details

How to Cite
Gunawijaya, F. A. (2008). The role of tea in cardiovascular disease. Universa Medicina, 27(3), 125–131. https://doi.org/10.18051/UnivMed.2008.v27.125-131
Section
Review Article

References

Department of Health Republic of Indonesia. Laporan studi mortalitas 2001: pola penyakit penyebab kematian di Indonesia. Jakarta: National Institute of Health, Research and Development; 2002.

Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Tea consumption and mortality after acute myocardial infarct. Circulation 2002; 105: 2474-79.

Weisburger JH. Tea and health; the underlying mechanism. Proc Soc Exp Biol 1999; 220: 271-5.

Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA. Flavonoids: areview o probable mechanismsof action and potential applications. Am J Clin Nutr 2001; 74: 418-25.

Egusa G, Yamane K. Lifestyle, serum lipids and coronary artery disease: comparison of Japan with the United State. J Atheroscler Thromb 2004; 11: 304-12.

Green Tea. Available at: http://www.umm.edu/altmed/articles/green-tea-000255.htm. Accessed May 26, 2007.

McKay DL, Blumberg JB. The role of tea in human health: an update. J Am Coll Nutr 2002; 21: 1-13.

Vinson J, Dabbagh Y, Serry M, Jang J. Plant flavonoids, especially tea flavonols, are powerful antioxidant using an in vitro oxidation model for heart disease. J Agri Food Chem 1995; 43: 2800-2.

Sesso H, Gaziano J, Buring J, Hennekens C. Coffee and tea intake and the risk of myocardial infarction. Am J Epidemiol 1999; 149: 162-7.

Geleijnse JM, Launer LJ, Van der Kuip DAM, Hofman A, Witteman JCM. Inverse association of tea and flavonoid intakes with incident myocardial infarction, the Rotterdam Study. Am J Clin Nut 2002; 75: 880-6.

Woodward M, Tunstall-Pedoe H. Coffee and tea consumption in the Scottish Heart Health Study follow up: conflicting relations with coronary risk factors, coronary disease and all cause mortality. J Epidemiol Commun Health 1999; 53: 481-7.

Peters U, Poole C, Arab L. Does tea affect cardiovascular disease? A meta-analysis. Am J Epidemiol 2001; 154: 495-503.

Poulter J, Bolton-Smith C, Rietveld A. Is there any evidence that tea drinking impacts on cardiovascular health in the UK? Br J Cardiol 2003; 10: 281-6.

Dreger H, Lorenz M, Kehrer A, Baumann G, Stangl K, Stangl V. Characteristics of catechin and theaflavin mediated cardioprotection. Experimental Biology and Medicine 2008; 233: 427-33.

Duffy SJ, Keaney Jr JF, Holbrook M, Gokce N, Swerdloff P, Frei B, et al. Short and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 2001; 104: 151-6.

Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysunction on adverse long-term outcome of coronary heart disease. Circulation 2000; 101: 1899-906.

Yoshida H, Ishikawa T, Hosoai H, Michio Suzukawa, Makoto Ayaori, Tetsuya Hisada, et al. Inhibitory effect of tea flavonoids on the ability of cells to oxidize low density lipoprotein. Biochem Pharmacol 1999; 58: 1695-703.

Duffy SJ, Vita JA, Holbrook M, Swerdloff PL, Keaney Jr JF. Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease. Arterioscler hromb Vasc Biol 2001; 21: 1084-9.

Yang C, Chung J, Yang G, Chhabra S, Lee M. Tea and tea polyphenols in cancer prevention. J Nut 2000; 130: 472S-478S.

Langley-Evans SC. Antioxidant potential of green and black tea determined using the ferric reducing antioxidant power (FRAP) assay. Int J Food Sci Nutr 2000; 51: 181-8.

Leenen R, Roodenburg A, Tijburg L, Wiseman S. A single dose of tea with or without milk increases plasma antioxidant activity in humans. Eur J Clin Nutr 2000; 54: 87-92.

Langley-Evans SC. Consumption of black tea elicits an increase in plasma antioxidant potential in humans. Int J Food Sci Nutr 2000; 51: 309-15.

Klaunig J, Xu Y, Han C, Kamendulis L, Chen J, Heiser C, et al. The effect of tea consumption on oxidative stress in smokers and non smokers. Proc Soc Exp Biol Med 1999; 220: 249-54.

Lean M, Noroozi M, Kelly I, Burns J, Talwar D, Sattar N, et al. Dietary flavanols protect diabetic human lymphocytes against oxidative damage to DNA. Diabetes 1999; 48: 176-81.

Freese R, Basu S, Hietanen E, Nair J, Nakachi K, Bartsch H, et al. Green tea extract decreases plasma malondialdehyde concentration but does not affect other indicators of oxidative stress, nitric oxide production, or hemostatic factors during a high-linoleic acid diet in healthy females. Eur J Nutr 1999; 38:149-57.

Zhang X, Zhao SP, Li XP, Gao M, Zhou QC. Endothelium-dependent and independent functions are impaired in patients with coronary heart disease. Atherosclerosis 2000; 149: 19-24.

Sargowo D. Peran endotel pada patogenesis penyakit kardiovaskular dan program pencegahannya. Medika 1999; 10: 643-54.

Sudjarwo SA. Protective effect of catechin on endothelial cell in hypercholesterolemia. J Kedokt Trisakti 2004; 23: 1-5.

Nagaya N, Yamamoto H, Uematsu M, Itoh T, Nakagawa K, Miyazawa T, et al. Green tea reverses endothelial dysfunction in healthy smokers. Heart 2004; 90: 1485-6.

Sasazuki S, Kodama H, Yoshimasu K, Liu Y, Washio M, Tanaka K, et al. Relation between green tea consumption and the severity of coronary atherosclerosis among Japanese men and women. Ann Epidemiol 2000; 10: 401-8.

Debette S, Courbon D, Leone N, Gariepy J, Tzourio C, Dartigues JF, et al. Tea consumption is inversely associated with carotid plaques in women. Arteriosclerosis, Thrombosis and Vascular. Biology 2008; 28: 353-59.

Wolfram S. Effects of green tea and EGCG on cardiovascular and metabolic health. J Am Coll Nutr 2007; 26: 373S-388S.