Formula Jamu Antihipertensi and captopril are equally effective in patients with hypertension

Main Article Content

Atina Hussaana
Hadi Sarosa
Ulfah Dian Indrayani
Chodidjah Chodidjah
Bagas Widiyanto
Danis Pertiwi


Hypertension is the main cause of morbidity and mortality associated with cardiovascular diseases. Many herbs/spices appear to have significant effects in favorably modulating high blood pressure. A jamu formulation containing 6 plant extracts, Formula Jamu Antihipertensi (FJA), has been described previously. This research study aimed to evaluate the effect of FJA as antihypertensive agent in mild to moderate hypertensive patients.

This double-blind experimental study was conducted in 40 hypertensive patients, who were randomized into two groups. The first group was treated with oral administration of 2 g FJA and the second group 25 mg captopril daily for 4 weeks. Systolic and diastolic blood pressure as well as liver and kidney function were followed up every week. Independent- t test and two-way ANOVA were used to analyze the data with a level of significance of 0.05.

The results showed that after the treatment, FJA and captopril were capable of significantly decreasing systolic and diastolic blood pressure (p <0.05). The decrease in systolic blood pressure between the two groups was identical (p>0.05), while the decrease in diastolic blood pressure was greater in the FJA group than in the captopril group (p <0.05).

From this study it may be concluded that administration of FJA for 4 weeks is equally effective as captopril in reducing systolic and diastolic blood pressure in patients with mild and moderate hypertension. Thus, natural plants and herbs can be our source of drugs, with fewer side effects and better bioavailability for treatment of hypertension in the future.

Article Details

How to Cite
Hussaana, A., Sarosa, H., Indrayani, U. D., Chodidjah, C., Widiyanto, B., & Pertiwi, D. (2016). Formula Jamu Antihipertensi and captopril are equally effective in patients with hypertension. Universa Medicina, 35(2), 81–88.
Original Articles
Author Biography

Atina Hussaana, Department of Pharmacology, Faculty of Medicine, Sultan Agung Islamic University

Departement Pharmacology and Therapy



Kementerian Kesehatan RI. Peraturan Menteri Kesehatan Republik Indonesia Nomor 003/MENKES/PER/2010 tentang saintifikasi jamu dalam penelitian berbasis pelayanan kesehatan. Jakarta; 2010.

Frishman WH, Beravol P, Carosella C. Alternative and complementary medicine for preventing and treating cardiovascular disease. Dis Mon 2009;55:121–92. doi: 10.1016/j.disamonth.2008.12.002.

Susalit E, Agus N, Effendi I, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with captopril. Phytomedicine 2001;18:251–8. doi: 10.1016/j.phymed.2010.08.016.4.

World Health Organization. Traditional medicine. Geneva: World Health Organization. Fact Sheet No 134;2008.

Vergara-Galicia J, Jimenez-Ramirez LÁ, Tun-Suarez A, et al. Vasorelaxant activity of extracts obtained from Apium graveolens: possible source for vasorelaxant molecules isolation with potential antihypertensive effect. Asian Pac J Trop Biomed 2013;3:776–9.

Moghadam AM, Imenshahidi M, Mohajeri SA. Antihypertensive effect of celery seed on rat blood pressure in chronic administration. J Med Food 2013;16:558–63.

Manshor NM, Dewa A, Asmawi MZ, et al. Vascular reactivity concerning Orthosiphon stamineus Benth-mediated antihypertensive in aortic rings of spontaneously hypertensive rats. Int J Vasc Med 2013, Article ID 456852, 8 pages

Gohil KJ, Patel JA, Gajjar AK. Pharmacological review on Centella asiatica: a potential herbal cure-all. Indian J Pharm Sci 2010;72:546-56. doi:10.4103/0250-474X.78519.

Tabassum N, Ahmad F. Role of natural herbs in the treatment of hypertension. Pharmacogn Rev 2011;5:30-40. doi:10.4103/0973-7847.79097.

Bharati D, Rawat S, Sharma P, et al. Evaluation of in vivo efficacy of aqueous leaf extract of Phyllanthus niruri in diabetic hypertensive rats. Ann Clin Exp Hypertension 2015;3:1031-7.

Supriyatna, Moelyono MW, Iskandar Y, et al. Mengenal obat herbal pemahaman obat herbal untuk fitoterapi. Bandung: Unpad Pres;2013.

Ahmad AF. Analisis penggunaan jamu untuk pengobatan pada pasien di klinik jamu Hortus Medicus Tawangmangu.[tesis]. Jakarta: Universitas Indonesia; 2012.

Febriyanti RM, Maesaroh I, Supriyatna, et al. Analisis farmakoekonomi saintifikasi jamu antihipertensi, antihiperglikemia, antihiper- kolesterolemia, dan antihiperurisemia. IJPST 2014;1:39-46.

Brankovic S, Kitic D, Radenkovic M, et al. Hypotensive and cardioinhibotory effects of the aqueous and ethanol extracts of Celery (Apium graveolens, Apiaceae). Acta Medica Medianae 2010;49:13-6.

Zhang YH, Park YS, Kim TJ. Endothelium-dependent vasorelaxant and antiproliperative effects of apigenin. Gen Pharmacol 2002;35:341-7.

Shafaei, Mun’im A, Lukmanto D, et al. Inhibition of angiotensin converting enzyme (ACE) activity by some Indonesia edible plants. IJPSR 2013;6:1054-9.

Adam Y, Somchit MN, Sulaiman MR, et al. Diuretic properties of Orthosiphon stamineus Benth. J Ethnopharmacol 2009;124:154-8.

Larson AJ, Adaramoye OA, Anjos RM, et al. Hypotensive and endothelium-independent vasorelaxant effects of methanolic extract from Centella asiatica in rats. J Ethnopharmacol 2012;124:457-62.

Iswantini D, Trisilawati O, Rahminiwati M, et al. Formula antihipertensi (>60%) captoril dari bahan aktif flavonoid pegagan, tempuyung, kumis kucing dan sambiloto dan budidaya untuk meningkatkan kandungan flavonoid (>1,5%). LPPM-IPB Darmaga;2010.

Siswoyo H. Formularium jamu untuk anti hipertensi, hiperglikemia, hiperurisemia, dan hiperkolestrolemia. Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI;2011.

Akram M, Shahab-Uddin, Ahmed A, et al. Curcuma longa and curcumin: a review article. Rom J Biol Plant Biol 2010;55:65–70.

Bhattacharjee R, Parames CS. Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem Toxicol 2007;45:817–26.

Harish R, Shivanandappa T. Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chem 2006;95:180–5.

Anwar MA, Al Disi SS, Eid AH. Anti-hypertensive herbs and their mechanisms of action: part II. Front Pharmacol 2016;7:50. doi: 10.3389/fphar.2016.00050.