Decreased erythrocyte superoxide dismutase in elderly men with early nuclear cataract

Article Sidebar

PDF
Published: Apr 19, 2014
DOI: https://doi.org/10.18051/UnivMed.2014.v33.65-72
Abstract Viewed: 289
PDF Downloaded: 1
Keywords:
Superoxide dismutase zinc testosterone fasting blood glucose early nuclear cataract elderly

Main Article Content

Rose Rose
Department of Ophthalmology Faculty of Medicine Trisakti University Jakarta
Erlani Kartadinata
Department of Ophthalmology Faculty of Medicine Trisakti University Jakarta

Abstract

BACKGROUND Imbalance between oxidative processes and antioxidant defenses has been considered to play a role in cataractogenesis, particularly in diabetes patients. Superoxide dismutase (SOD) is an important precursor for oxidative stress in the human lens, and its activity is mainly dependent on the copper and zinc levels in the body. The aim of this study was to compare erythrocyte SOD, erythrocyte zinc and total serum testosterone levels in male patients with early senile nuclear cataract and evaluate the correlations between the parameters in all subjects. METHODS A community-based study of cross-sectional design was conducted at Cilandak District Primary Health Center where 52 adult and 17 elderly men with early senile nuclear cataract were chosen as the study subjects. Erythrocyte SOD, erythrocyte zinc, serum testosterone, and fasting blood glucose (FBG) levels were measured in all subjects. Nuclear cataract stage was assessed with the Pentacam® instrument (Oculus, Germany). Independent Student t test and Pearson’s correlation were used to analyze the results. RESULTS Erythrocyte SOD level was significantly decreased in elderly men compared to adult men (p=0.014). Erythrocyte zinc, serum testosterone and FBG did not differ significantly in adult and elderly males (at p=0.304; p=0.145;and p=0.376, respectively). Erythrocyte SOD activity was significantly associated with erythrocyte zinc level (r=0.486; p=0.048). CONCLUSIONS Lower erythrocyte SOD activity was found in elderly males than in adult males with early nuclear cataract. There was a relationship between erythrocyte SOD and erythrocyte zinc level in elderly males with early nuclear cataract.

Article Details

How to Cite
Rose, R., & Kartadinata, E. (2014). Decreased erythrocyte superoxide dismutase in elderly men with early nuclear cataract. Universa Medicina, 33(1), 65–72. https://doi.org/10.18051/UnivMed.2014.v33.65-72
Issue
Vol. 33 No. 1 (2014)
Section
Review Article
The journal allow the authors to hold the copyright without restrictions and allow the authors to retain publishing rights without restrictions.

References

World Health Organization. Global data on

visual impairments 2010. Available at: http://

www.who.int/blindness/GLOBALDATAFINAL

forweb.pdf. Accessed December 1, 2013.

Cugati S, Cunming RG, Smith W, Burlutsky G,

Mitchell P, Wang JJ. Visual impairment, age71

related macular degeneration, cataract, and longterm

mortality: the Blue Mountains Eye Study.

Arch Ophthalmol 2007;125:917-24.

Ocampo VVD, Roy HR. Senile cataract.

Available at: http://www.emedicine.medscape.

com/article/1210914-overview. Accessed June 3,

Yildirim Z, Yildirim F, Uegun NI, Kilie N. The

evaluation of the oxidative stress parameters in

non-diabetic and diabetic senile cataract patients.

Niol Trace Elem Res 2009;128:135-43.

Hasim Z, Zarina S. Osmotic stress induced

oxidative damage: possible mechanism of

cataract formation in diabetes. J Diabet

Complications 2012:26:275-9.

Giacco F, Brownlee M. Oxidative stress and

diabetic complications. Circ Res 2010;107:1058-

McGinty SJ, Truscott RJW. Presbyopia: the first

stage of nuclear cataract? Ophthalmic Res 2006;

:137-48.

Robman L, Taylor H. External factors in the

development of cataract. Eye 2005;19:1074-82.

Praveen MR, Shah GD, Vasavada AR, Mehta

PG, Gilbert C, Bhagat G. A study to explore the

risk factors for the early onset of cataract in India.

Eye 2010;24:686-94.

Fletcher AE. Free radicals, antioxidants and eye

diseases: evidence from epidemiological studies

on cataract and age-related macular

degeneration. Ophthalmic Res 2010;44:191-8.

Tarwadi K, Agte V. Linkages of antioxidant,

micronutrient, and socioeconomic status with the

degree of oxidative stress and lens opacity in

Indian cataract patients. Nutrition 2004;20:261-

Virgolici B, Stoian I, Muscurel C, Maracine M,

Popescu L, Moraru C, et al. Systemic redox

modifications in senile cataract. Rom J Intern

Med 2009;47:279–87.

Karppi J, Laukkanen JA, Kurl S. Plasma lutein

and zeaxanthin and the risk of age-related

nuclear cataract among the elderly Finnish

population. Br J Nutr 2012:108:148-54.

Christen WG, Liu S, Glynn RJ, Gaziano M,

Buring JE. Dietary carotenoids, vitamin C and

E, and risk of cataract in women. Arch

Ophthalmol 2008;126:102-9.

Agte V, Tarwadi K. The importance of nutrition

in the prevention of ocular disease with special

reference to cataract. Ophthal Res 2010;44:166-

Chakraborty I, Kunti S, Bandyopadhyay,

Dasgupta A, Chattopadhyay GD, Chakraborty

S. Evaluation of serum zinc level and plasma

SOD activity in senile cataract patients under

oxidative stress. Ind J Biochem Ciophys 2007;22:

-13.

Miric DJ, Kisic BB, Zoric LD, Mitic RV, Miric

BM, Dragojevic IM. Xanthine oxidase and lens

oxidative stress markers in diabetic and senile

cataract patients. J Diabet Complications 2013;

:171-6.

Donma O, Yorulmaz E, Pekel H, Suyugul N.

Blood and lens lipid peroxidation and

antioxidant status in normal individuals, senile

and diabetic cataractous patients. Curr Eye Res

;25:9-16.

Giton F, Urien S, Born C, Tichet J, Guechot J,

Jacques C, et al. Determination of bioavailable

testosterone [non-sex-hormone-binding globulin

(SHBG)-bound testosterone] in a population of

healthy French men: influence of androstenediol

on testosterone binding to SHBG. Clin Chem

;53:2160-8.

Korsakova NV, Sergeeva VE, Petrov SB.

Immunohistochemical analysis of lens cells on

formation of different types of age-related

cataract in humans. Neurosci Behav Physiol

;38:887-90.

Villareal DT, Apovian CM, Kushner RF, Klein

S. Obesity in older adults: technical review and

position statement of the American Society for

Nutrition and NAASO, the obesity society. Obes

Res 2005;13:1849-63.

Ye J, Lou LX, He JJ, Xu YF. Body mass index

and risk of age-related cataract: a meta-analysis

of prospective cohort studies. PloS ONE

:9:e89923. doi:10.1371/journal.pone.00899

Park YH, Shin JA, Han K, Yim HW, Lee WC,

Park YM. Gender difference in the association

of metabolic syndrome and its components with

age-related cataract: the Korea national health

and nutrition examination survey 2008-2010.

PLoS ONE 2014;9:e85068. doi:10.1371/journal.

pone.0085068.

Kinoyama M, Nitta H, Hara S, Watanabe A,

Shirao K. Blood superoxide dismutase (SOD)

decrease following oral administration of plant

SOD to healthy subjects. J Health Sci 2007;53:

-14.

Kawai K, Hayashi T, Matsuyama Y, Minami T,

Era S. Difference in redox status of serum and

aqueous humor in senile cataract patients as

monitored via the albumin thiol-redox state. Jpn

J Ophthalmol 2010;54:584-8.

Dawczynski J, Blum M, Winnefeld K, Strobel J.

Increased content of zinc and iron in human

cataractous lenses. Biol Trace Element Res 2002;

:15-23.

Jamil SA, Naseer SA, Noreen K. Comparison

in effect of different metal ions, pH and reducing

agent on the protease activity in human

hypermature and mature cataract. J Zhejiang

Univ Sci B 2007;8:599-603.

Gunduz G, Gunduz F, Yucel I, Senturk UK.

Levels of zinc and magnesium in senile and

diabetic senile cataractous lenses. Biol Trace

Element Res 2003;95:107-12.