Shortening tends to increase aortic foam cell count and wall thickness in male Wistar rats

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Rokhima Lusiantari
Miranti Dewi Pramaningtyas
Titis Nurmasitoh
Rachmi Hidayati Pattimura
Anggita Dewanti


Shortening is widely used as raw material for bread and other foods. Hypercholesterolemia increases aortic arch foam cell formation and abdominal aortic wall thickness. This study aimed to determine the effect of shortening on the number of aortic arch foam cells and abdominal aortic wall thickness in rats.

This study was of experimental posttest control group design. Twenty four male Wistar rats were randomized into 4 groups. The negative control group (C-) received standard feed, the positive control group (C+) standard high-fat feed, group T1 shortening and standard feed at a ratio of 1:5 and group T2 shortening and standard feed at a ratio of 1:10. The interventions were given for 6 weeks through gavage. The foam cell count in the aortic arch and the thickness of the abdominal aortic wall were measured. One-way ANOVA test was used to analyze the data.


There was no significant difference in the mean foam cell count of the aortic arch between the four groups C- (7.17 ± 4.17), C + (9.33 ± 7.01), T1 (11.83 ± 4.88) and T2 (9.33 ± 6.80) (p=0.598). The mean thickness of the abdominal aortic wall between the four groups C- (741.98 ± 60.67μm), C + (714.29 ± 90.59μm), T1 (838.90 ± 75.86 μm), and T2 (749.88 ± 99.37μm) also was not significantly different (p=0.110).

Shortening tends to increase the foam cell count of the aortic arch and the thickness of the abdominal aortic wall of rats.

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How to Cite
Lusiantari, R., Pramaningtyas, M. D., Nurmasitoh, T., Pattimura, R. H., & Dewanti, A. (2018). Shortening tends to increase aortic foam cell count and wall thickness in male Wistar rats. Universa Medicina, 37(1), 13–18.
Original Articles
Author Biography

Rokhima Lusiantari, Department of Physiology Faculty of Medicine University of Islam Indonesia

Departemen Fisiologi


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