Main Article Content
Shortening is widely used as raw material for bread and other foods. Hypercholesterolemia increases aortic arch foam cell formation and abdominal aortic wall thickness. This study aimed to determine the effect of shortening on the number of aortic arch foam cells and abdominal aortic wall thickness in rats.
This study was of experimental posttest control group design. Twenty four male Wistar rats were randomized into 4 groups. The negative control group (C-) received standard feed, the positive control group (C+) standard high-fat feed, group T1 shortening and standard feed at a ratio of 1:5 and group T2 shortening and standard feed at a ratio of 1:10. The interventions were given for 6 weeks through gavage. The foam cell count in the aortic arch and the thickness of the abdominal aortic wall were measured. One-way ANOVA test was used to analyze the data.
There was no significant difference in the mean foam cell count of the aortic arch between the four groups C- (7.17 ± 4.17), C + (9.33 ± 7.01), T1 (11.83 ± 4.88) and T2 (9.33 ± 6.80) (p=0.598). The mean thickness of the abdominal aortic wall between the four groups C- (741.98 ± 60.67μm), C + (714.29 ± 90.59μm), T1 (838.90 ± 75.86 μm), and T2 (749.88 ± 99.37μm) also was not significantly different (p=0.110).
Shortening tends to increase the foam cell count of the aortic arch and the thickness of the abdominal aortic wall of rats.
The journal allows the authors to hold the copyright without restrictions and allow the authors to retain publishing rights without restrictions.
Carmen G, Iliescu C. Modern risk stratification in coronary heart disease. J Med Life 2011;4:377-86.
Rohilla A, Dagar N, Rohilla S, et al. Hyperlipidemia- a deadly pathological condition. Int J Curr Pharm Res 2012;4:15-8.
Finegold JA, Asaria P, Francis DP. Mortality from ischaemic heart disease by country, region, and age: Statistics from World Health Organisation and United Nations. Int J Cardiol 2013;168: 934-45.
World Health Organization. Global status report on noncomunicable disease 2010. Geneva: World Health Organization;2011.
Harikumar K, Althaf SA, Kishore KB, et al. A review on hyperlipidemic. Int J Nov Trends Pharm Sci 2013;3:69–80.
Bonomini F, Rodella LF, Rezzani R. Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis 2015;6:109–20.
Csonka C, Sarkozy M, Pipicz M, et al. Modulation of hypercholesterolemia-induced oxidative/nitrative stress in the heart. Oxid Med Cell Longev 2016;2016:1-23.
Alkhamees OA. Protective effects of vitamin-P and vitamin-C on hypercholesterolemia-induced oxidative hepatic damage and lipid profile changes in female rats: a comparative study. J Appl Pharm Sci 2013;3:99–105.
Dewi NCP, Probosari E. Pengaruh pemberian ekstrak kacang hijau (Phaseolus radiatus) terhadap kadar kolesterol LDL serum tikus hiperkolesterolemia. J Nutr Coll 2013;2:585-92.
Maramis R, Kaseke MK, Tanudjadja GN. Gambaran histologi aorta tikus wistar dengan diet lemak babi setelah pemberian ekstrak daun sirsak (annona muricata). J Biomedik 2014;2:431-35.
Nurmasitoh T, Pramaningtyas MD. Honey improves lipid profile of diet-induced hypercholesterolemic rats. Univ Med 2015;34:177-86.
Mamat H, Hill SE. Effect of fat types on the structural and textural properties of dough and semi-sweet biscuit. J Food Sci Technol 2014;51: 1998-2005.
Jissy Jacob, Leelavathi K. Effect of fat-type on cookie dough and cookie quality. J Food Eng 2007;79:299–305.
Tomkin GH, Owens D. LDL as a cause of atherosclerosis. Open Atherosclerosis Thromb J 2012;5:13-21.
Eckel RH, Borra S, Lichtenstein AH, et al. Understanding the complexity of trans fatty acid reduction in the American diet. Circulation 2007; 115:2231-46.
Dahlan S. Statistik untuk Kedokteran dan Kesehatan Edisi 6. Epidemiologi Indonesia. Jakarta; 2014.
Welinsa F, Asni E, Malik Z, et al. Histopatologi arteri torasika Rattus novergicus strain wistar jantan setelah 8 minggu pemberian diet aterogenik. JOM FK 2014;2:1-11.
Bentzon JF, Otsuka F, Virmani R, et al. Mechanisms of plaque formation and rupture. Circ Res 2014; 114:1852-1866.
Porth CM, Grossman S, editors. Porth’s pathophysiology concepts of altered health states. 9th ed. Philadelphia: Wolters Kluwer Health: Lippincott Williams & Wilkins;2014.
Callisa O, Handayani D, Tritisari KP. Pengaruh pemberian tepung daun katuk terhadap penebalan dinding aorta tikus wistar. Indones J Human Nutr 2015;2:85-90.
Heriansyah T. Pengaruh berbagai durasi pemberian diet tinggi lemak terhadap profil lipid tikus putih (Rattus norvegicus strain Wistar) jantan. J Kedokt Syah Kuala 2013;13:114-50.