ISSN 2407-2230 | E-ISSN 1907-3062 | Universa Medicina content is searchable on DOAJ, Google Scholar, and OAI

Hypoglycemic effect of Phaleria macrocarpa (Scheff.) Boerl dry extract in healthy adults

Meiyanti Meiyanti, Eveline Margo, Pusparini Pusparini, Lie Tanu Merijanti, Alvina Lesmana
Submission date: Tuesday, 14 August 2018
Published date: Wednesday, 14 November 2018
DOI: http://dx.doi.org/10.18051/UnivMed.2018.v37.195-202

Abstract


Background
The prevalence of diabetes in Indonesia continues to increase and causes many complications. Fruits of Phaleria macrocarpa (Scheff.) Boerl. (PM) are used in the traditional health system of the Indonesians, as effective remedy in the management of diabetes mellitus. The aim of this study was to evaluate the effect and magnitude of doses of PM dry fruit extract (PME) on blood glucose levels in healthy adults.

Methods
This research was of pre-posttest design involving 30 healthy volunteer subjects aged 20-55 years receiving glucose loads. At pre-test the subjects were given orally 75 g glucose, and at post-test they were given PME at doses of 125 mg and 250 mg. Data collection included anthropometric examination and blood glucose level. The area under the curve (AUC) of blood glucose levels was measured at 0, 15, 30, 60, 120 and 180 minutes. Data analysis was performed using paired t-test with p <0.05.

Results
The percentage of reduction in AUC between pre- and post-test after administration of PME 125 mg was 12.1% and significant (p=0.000). But the percentage of reduction in AUC between pre- and post-test after administration of PME 250 mg was 4.07% and not significant (p=0.06). The reduction in AUC between post-test PME 125 mg vs PME 250 mg showed significant results (p=0.011).

Conclusion
This study demonstrated that a dose of 125 mg Phaleria macrocarpa (Scheff.) Boerl. dry extract has a hypoglycemic effect in healthy adults, and may therefore be suitable for use as traditional anti-diabetic drug.

Keywords


Phaleria macrocarpa; extract; blood glucose; healthy adult

Full Text:

PDF

References


Govindappa M. A review on role of plant(s) extracts and its phytochemicals for the management of diabetes. J Diabetes Metab 2015; 6:565. doi: 10.4172/2155-6156.10000565.

Lee SY, Mediani A, Nur Ashikin AH, et al. Antioxidant and á-glucosidase inhibitory activities of the leaf and stem of selected traditional medicinal plants. IFRJ 2014;21:165-72.

Ali RB, Atangwho IJ, Kuar N, et al. Hypoglycemic and antihyperglycemic study of Phaleria macrocarpa fruits pericarp. J Med Plant Res 2012;6:1982-90. doi: 10.5897/JMPR11.1683.

Othman SNAM, Sarker SD, Nahar L, et al. The ethnomedicinal, phytochemical and pharmacological properties of Phaleria macrocarpa (Scheff). Boerl. Tang Humanitas Med 2014;4:1-11. DOI: http://dx.doi.org/10.5667/tang2014.0018.

Elya B, Handayani R, Sauriasari R, et al. Antidiabetic activity and phytochemical screening of extracts from Indonesian plants by inhibition of alpha amylase, alpha glucosidase and dipeptidyl peptidase IV. Pak J Biol Sci 2015;18: 279-84. doi: 10.3923/pjbs.2015.279.284

International Diabetes Federation. Diabetes evidence demands real action from the UN summit on non-communicable diseases. Belgium: International Diabetes Federation;2011.

Triastuti A, Park HJ, Choi JW. Phaleria macrocarpa suppress nephropathy by increasing renal antioxidant enzyme activity in alloxan-induced diabetic rats. Nat Prod Sci 2009;15:167-72.

Ali R, Atangwho IJ, Kuar N, et al. In vitro and in vivo effects of standardized extract and fractions of Phaleria macrocarpa fruits pericarp on lead carbohydrate digesting enzymes. BMC Complement Alternative Med 2013;13:39. DOI: http://www.biomedcentral.com/1472-6882/13/39.

Kim W, Veriansyah B, Lee Y, et al. Extraction of mangiferin from mahkota dewa (Phaleria macrocarpa) using subcritical water. J Ind Eng Chem 2010;16:425-30. doi: 10.1016/j.jiec.2009. 08.008.

Hending W, Ermin KW. Benzophenone glucoside isolated from ethyl acetate extract of the bark of mahkota dewa (Phaleria macrocarpa (Scheff) Boerl.) and its inhibitory activity on L1210 cel line. Indones J Chem 2009:142-5. DOI: http://dx.doi.org/10.22146/ijc.473.

Meiyanti, Dewoto HR, Suyatna FD. Efek hipoglikemik daging buah Mahkota dewa (Phaleria Macrocarpa (Scheff) Boerl) terhadap kadar gula darah pada manusia sehat setelah pembebanan glukosa. Univ Med 2006;25:114-20.

Altaf R, Bin Asmawi MZ, Sadikin A, et al. Phytochemistry and medicinal properties of Phaleria acrocarpa (Scheff.) Boerl. extracts. Pharmacogn Rev 2013;7:73-80. doi: 10.4103/0973. 7847.112853.

Alara OR, Olalere OA. A critical overview on extraction of bioactive compounds from Phaleria macrocarpa (Thymelaceae). Nat Prod Chem Res 2016;4:5. DOI: http://dx.doi/10.4172/2329-6836.10000232.

Azwanida NN. A review on the extraction methods use in medicinal plants: principle, strength, and limitation. Med Aromat Plants 2015;4:3. DOI : http://dx.doi.org/10.4172/2167-0412.1000196.

Rahmi E. Wahyuni WT, Darusman LK, et al. Combination of ethanolic extract of á-glucosidase inhibitory activity of (Phaleria macrocarpa (Scheff.) Boerl.) fruits and Annona muricata Linn. leaves. Trad Med J 2016;21:63-8. doi: https://doi.org/10/22146/tradmedj.12819.

Purnamasari D. Diagnosis dan klasifikasi diabetes mellitus. In: Setiati S, Alwi I, Sudoyo AW, editors. Buku ajar ilmu penyakit dalam Jilid II Edisi VI. Jakarta: Interna Publishing; 2014.p.2325-9.

Scheff JD, Almon RR, DuBois DC, et al. Assessment of pharmacologic area under the curve when baselines are variable. Pharm Res 2011:28: 1081-9. doi: 10.1007/s11095-010-0363-8.

Chotimah C, Sutrisna EM, Wahyuni AS. Water extract of jaka tuwa (Scoparia dulcis L) herb activity on lowering blood glucose on male rabbit that loaded with glucose. Pharmacon 2008;9:46-51.

Muhtadi A, Hendriani R, Mustarichie R. Pharmacological screening of various Indonesian herbal potentially used as antidiabetic. IRJPAS 2013;3:90-5. doi: 10.1038/ncomms9482.

Anggraeni DN. Pengaruh pemberian variasi dosis pupuk kandang terhadap pertumbuhan tanaman mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.). Biogenesis 2014;2:16-20.doi:https://doi.org/10.24525/bio.v.2i1.463.

Ali RB, Atangwho IJ, Kuar N, et al. Bioassay-guided antidiabetic study of Phaleria macrocarpa fruits extract. Molecules 2012:17: 4986-5002. doi: 10.3390/molecules17054986.

Azmir J, Zaidul ISM, Sharif KM, et al. Supercritical carbon dioxide extraction of highly unsaturated oil from Phaleria macrocarpa seed. FRIN 2014; 65:394-400. doi: 10.1016/j.foodres2014.06.049.

Andrean D, Prasetyo S, Kristijarti AP, et al. The extraction and activity test of bioactive compounds in Phaleria macrocarpa as antioxidants. Procedia Chem 2014;9:94-101. doi: 10.1016/j.proche.2014.05.012.

Sabina E, Zaidul ISM, Ghafoor K, et al. Screening of various part of macrocarpa plant for á-glucosidase inhibitory activity. J Food Biochem 2016; 40:201-10. DOI: https://doi.org/10.1111/jfbc.12212.

Ramachandran B, Rajasekaran S. Blood glucose lowering effect of Tectona grandis flowers in type 2 diabetic rats: a study on identification of active constituents and mechanisms for antidiabetic action. J Diab 2014;6:427-37. doi: 10.1111/1753-0407.1212.

Cicero L, Yenshou L, Arlene PB, et al. Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evidence-based Comp Alt Med 2013:33-6. doi: http://dx.doi.org/10.1155/2013/378657.

Arjadi F, Mustofa. Ekstrak daging buah mahkota dewa meregenerasi sel Pulau Langerhans pada tikus putih diabetes. Biogenesis 2017;5:27-33. doi: http://dx.doi.org/10.24252/bio.v4i2.3430.

Aziz MTA, El-Asmar MF, Rezq AM. The effect on a novel curcumin derivative on pancreatic islet regeneration in experimental type 1 diabetes in rats (long term study). Diabet Metab Synd 2013;5: 75. doi: 10.1186/1758-5996-5-75.

Hendra R, Achmad S, Sukari S, Shukor YM. Flavonoid analyses and antimicrobial activity in various parts of Phaleria macrocarpa (Scheff.) Boerl fruit. Int J Mol Sci 2011:3422-3.doi:10.3390/ijms12063422.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 Universa Medicina

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Creative Commons License
Universa Medicina by Faculty of Medicine, Trisakti University is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Based on a work at https://univmed.org/ejurnal/index.php/medicina/