Advanced metastatic breast carcinoma in sickle cell disease

Main Article Content

Marcellinus uchechukwu Nwagu
Ologo Thompson
Akinola Oyekemi


Breast cancer is the leading cancer in women leading to over 400,000 deaths per year worldwide. It begins in the breast tissue and can metastasize to other organs if early diagnosis and treatment is not instituted. Women with sickle cell disease are usually spared from breast cancer and other solid tumours due to the tumoricidal effect of sickled erythrocytes. Breast cancers are rare among these group of patients. Despite its rare occurrence, this paper was to emphasize the need for breast cancer screening among female sickle cell disease patients who have positive family history of breast cancer.

Case description
OO was a 30-year old woman with sickle cell disease who presented to the hospital one and half years ago with a seven months history of right breast swelling and pains. She had lost her mother to breast cancer about 15 years ago. Mammography and histology of breast biopsy confirmed diagnosis of invasive ductal carcinoma of the right breast. Financial constraint was a major challenge in managing this patient as she was unable to buy her chemotherapy. She developed features suggestive of metastasis such as seizures and hepatomegaly. She was stabilized and discharged home but we lost her to follow up. She died at home.

Breast cancer is rare among females with sickle cell disease; any of them with a family history should be routinely screened for early diagnosis and treatment.

Article Details

How to Cite
Nwagu, M. uchechukwu, Thompson, O., & Oyekemi, A. (2019). Advanced metastatic breast carcinoma in sickle cell disease. Universa Medicina, 38(2), 139–143.
Case Report


Nwagu MU. Sickle cell disease: review of complications, current and emerging trends in management. Ebonyi Med J 2011;10:84-92.

Brunson A, Keegan THM, Bang H, et al. Increased risk of leukemia among sickle cell disease patients in California. Blood 2017;130:1597-9 . doi: 10.1182/blood-2017-05-783233.

Ghoncheh M, Pournamdar Z, Salehiniya H. Incidence and mortality and epidemiology of breast cancer in the world. Asian Pac J Cancer Prev 2016; 17:43-6.

World Health Organization. Global health estimates. Geneva: World Health Organization;2013. U.S breast cancer statistics. Ardmore, PA. US;;2019.

Osaro E. Breast cancer in Nigeria: diagnosis, management and challenges. Bloomington, IN, USA: Author House;2016.

Okobia MN, Bunker CH, Okonofua FE, et al. Knowledge, attitude and practice of Nigerian women towards breast cancer: a cross-sectional study. World J Surg Oncol 2006; 4: 11–5.

Kundu JK, Surh YJ. Emerging avenues linking inflammation and cancer. Free Radic Biol Med 2012; 52:2013-37. doi: 10.1016/j.freeradbiomed.2012.02.035

Crusz SM, Balkwill FR. Inflammation and cancer: advances and new agents. Nat Rev Clin Oncol 2015;12: 584-96. doi: 10.1038/nrclinonc.2015.105.

Aggarwal BB, Shishodia S, Sandur SK, et al. Inflammation and cancer: how hot is the link? Biochem Pharmacol 2006;72:1605-21.

Chung WS, Lin CL, Lin CL, et al. Thalassaemia and risk of cancer: a population-based cohort study. J Epidemiol Community Health 2015;69:1066-70. doi : 10.1136/jech-2014-205075.

Zacharski LR, Chow BK, Howes PS, et al. Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial. J Natl Cancer Inst 2008;100:996-1002.

Terman DS, Viglianti BL, Zennadi R, et al. Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response. PLoS One 2013;8:e52543. doi: 10.1371/journal.pone.0052543.

Tabouret E, Chinot O, Metalus P, et al. Recent trends in the epidemiology of brain metastasis: an overview. Anticancer Res 2012;32:4655-62.

Olatunwa O, Ogundare EO, Fadare J. The financial burden of sickle cell disease on households in Ekiti, Southwest Nigeria. Clinicoecon Outcomes Res 2015;7:545-53. doi: 10.2147/CEOR.S86599.

Al Zaman AS. Breast cancer in patients with sickle cell disease can be treated safely with weekly paclitaxel. Saudi Med J 2013;34:199-201.

Brown BJ, Okereke JO, Lagunju IA, et al. Burden of health-care on carers of children with sickle cell disease in Nigeria. Health Soc Care Community 2010;18:289-95. doi: 10.1111/j.1365-2524.2009.00903.x.

Boyd NF, Martin LJ, Yaffe MJ, et al. Mammographic density and breast cancer risk: current understanding and future prospects. Breast Cancer Res 2011;13:223. doi: 10.1186/bcr2942.