Soy-isoflavone supplementation tends to reduce menopausal symptoms in postmenopausal women

Main Article Content

Raditya Wratsangka
Atut Cicih Mayasari

Abstract

BACKGROUND
Menopausal symptoms in postmenopausal women tend to decrease healthrelated quality of life (HRQoL). The present study’s objective was to determine the effect of daily supplementation of 100 mg soy isoflavones on menopausal
symptoms of healthy postmenopausal women. Isoflavones are phytoestrogens abundantly found in soy beans, and several studies have demonstrated that isoflavones are the best among the phytoestrogens.
METHODS
The study was a community-based double blind randomized controlled trial involving 60 healthy postmenopausal women, aged between 48–60 years, in the Mampang Prapatan District, South Jakarta. Participants were block-randomized to receive either 100 mg soy-isoflavone + 500 mg calcium carbonate (intervention group) or 500 mg calcium carbonate only (control group). Both supplements were taken daily for 12 weeks, from January to April 2010. Menopausal symptoms
(measured by Menopause Rating Scale questionnaire) were assessed at baseline and after supplementation. Chi-square test was used to examine the effect of soy isoflavone supplementation on menopausal symptoms.
RESULTS
Fifty-six (93.3%) of participants completed the study. There were no statistically significant differences (p>0.05) in the prevalence of menopausal symptoms between the isoflavone group and the control group. However, supplementation
of soy isoflavones for 12 weeks tended to decrease the prevalence of menopausal symptoms in women with normal body mass index and adequate daily dietary isoflavone intake.
CONCLUSION
Daily supplementation of 100 mg soy isoflavones for 12 weeks tend to decrease the incidence of menopausal symptoms in postmenopausal women.

Article Details

How to Cite
Wratsangka, R., & Mayasari, A. C. (2013). Soy-isoflavone supplementation tends to reduce menopausal symptoms in postmenopausal women. Universa Medicina, 32(2), 118–127. https://doi.org/10.18051/UnivMed.2013.v32.118-127
Section
Review Article
Author Biographies

Raditya Wratsangka, Trisakti University

Department of Obstetrics and Gynecology
Faculty of Medicine

Atut Cicih Mayasari, Trisakti University

Department of Obstetrics and Gynecology
Faculty of Medicine

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