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Parkinson's disease and the welding job: are both related?

Iqbal Mochtar, Muchtaruddin Mansyur
Submission date: Friday, 07 June 2019
Published date: Monday, 16 March 2020
DOI: http://dx.doi.org/10.18051/UnivMed.2020.v39.63-70

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Abstract


Up to the present, there has been a controversy on the relationship between Parkinson’s disease and the welding job. The aim of this study was to obtain evidence-based information regarding the relationship between Parkinson’s disease and the welding job through an evidence-based case report derived from a literature review. The review was conducted through a method of search and selection of articles in the Pubmed, Cochrane Library and JSTOR databases aimed at answering the study question. The process of searching articles used the keywords “Welding” OR “Welder” AND “Parkinson”. Article selection was performed using the defined inclusion and exclusion criteria. At the initial search, 117 articles were retrieved from the three databases. Following the selection process, three articles remained, which consisted of one systematic review and two observational studies. Comparing the selected articles, the systematic review of Mortimer et al. is more relevant and appropriate for answering the clinical question. Mortimer et al. used a meta-analytical method, applied strict inclusion and exclusion criteria and excluded studies that potentially led to bias effects, lack of validity or inadequate statistical methods. Based on the selected evidence-based resources, Parkinson’s disease is not related to the welding job. The welding job, however, may produce clinical symptoms and signs resembling Parkinson’s disease, known as manganism.


Keywords


Welding; Parkinson’s disease; evidence-based; case report

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References


Rocca WA. The burden of Parkinson’s disease: a worldwide perspective. Lancet Neurol 2018;17: 928-9. doi: 10.1016/S1474-4422(18)30355-7.

Oertel WH. Recent advances in treating Parkinson’s disease. F1000Res 2017;6:260. doi: 10.12688/f1000research.10100.1.

DeMaagd G, Philip A. Parkionson’s disease and its management. PT 2015;40:504-32.

Ascherio A, Schwarzschild MA. The epidemiology of Parkinson’s disease: risk factors and prevention. Lancet Neurol 2016;15:1257-72. DOI: https://doi.org/10.1016/S1474-4422(16) 30230-7.

Xu Y, Yang J, Shang H. Meta-analysis of risk factors for Parkinson’s disease dementia. Transl Neurodegener 2016;5:1-8.

Park RM. Neurobehavioral deficits and Parkinsonism in occupations with manganese exposure: a review of methodological issues in the epidemiological literature. Saf Health Work 2013;4:123-35.

Glasziou PP, Mar CD, Salisbury J. Evidence-Based Practice Workbook. 2nd ed. London: Blackwell Publishing - BMJ Books; 2007.

Oxford Centre for Evidence Based Medicine (CEBM). Critical Appraisal Tools. Oxford;2019.

Mortimer JA, Borenstein AR, Nelson LM. Associations of welding and manganese exposure with Parkinson’s disease: review and meta-analysis. Neurology 2012;79:1174-80.

Racette BA, Criswell SR, Lundin JI, et al. Increased risk of Parkinsonism with welding exposure. Neurotoxicology 2012;33:1356-61.

Racette BA, Nielsen SS, Criswell SR, et al. Dose-dependent progression of Parkinsonism in manganese-exposed welders. Neurology 2017;88: 344-51.

Couper J. On the effects of black oxide of manganese when inhaled in the lungs. Br Ann Med Pharmacol 1873;1:41–2. Cited by: Blanc PD. The early history of manganese and the recognition of its neurotoxicity, 1837-1936. Neurotoxicology 2018;64:5-11. doi: 10.1016/j.neuro.2017.04.006.

Kwakye GF, Paoliello MMB, Mukhopadhyay S, et al. Manganese-induced Parkinsonism and Parkinson’s disease: shared and distinguishable features. Int J Environ Res Public Health 2015;12: 7519-40.

Guilarte TR. Manganese and Parkinson’s disease: a critical review and new findings. Environ Health Perspect 2010;118:1071-81.

Reeve A, Simcox E, Turnbull D. Ageing and Parkinson’s disease: why is advancing age the biggest risk factor? Ageing Res Rev 2014;14:19-30.


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Copyright (c) 2020 Iqbal Mochtar, Muchtaruddin Mansyur

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Universa Medicina by Faculty of Medicine, Trisakti University is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Based on a work at https://univmed.org/ejurnal/index.php/medicina/