Effect of Brain Gym ® exercises on cognitive function and brain-derived neurotrophic factor plasma level in elderly: a randomized controlled trial
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Abstract
Cognitive impairment and dementia are some of the major health concerns in the aging population. Many studies showed positive effects of physical exercise in delaying or preventing these conditions. Brain Gym ® exercises is a structured aerobic exercise involving head, eyes and crossing movements of the extremities in order to stimulate both brain hemispheres. This study was conducted to evaluate the effect of Brain Gym ® exercises sessions on cognitive function and plasma brain-derived neurotrophic factor (BDNF) in the elderly.
Methods
A non-blinded randomized controlled study involving 64 healthy women aged >60 years who were randomized into Brain Gym ® exercises treatment group (n=32) and control group (n=32). Treatment group joined 60 minutes of brain gym exercises sessions twice a week for 12 weeks. The measured outcomes were cognitive function (assessed by mini-mental state examination [MMSE] questionnaire) and plasma BDNF levels. The outcomes were measured at base-line and after the intervention. An independent t-test was used to analyze the data.
Results
The BDNF levels were increased in both groups after 12 weeks, and there was a significant difference between treatment group (41.26 ± 6,82 ng/mL) and control group (37.10 ± 8.11 ng/mL)(p=0.040). However, the MMSE score was not significantly different between the two groups (p=0.200).
Conclusion
Brain Gym ® exercises sessions significantly increase plasma BDNF level in the elderly population. In practical terms, we may suggest evaluation of the effects of Brain Gym ® exercises as a strategy in the treatment of disorders associated with central degenerative changes.
Article Details
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References
Kementerian Kesehatan RI. Analisis lansia di Indonesia. Jakarta: Pusat Data dan Informasi Kementerian Kesehatan RI;2017.
United Nations Population Fund (UNFPA) Indonesia. Indonesia on the threshold of population ageing. Jakarta : United Nations Population Fund (UNFPA) Indonesian;2014.
Mavrodaris A, Powell J, Thorogood M. Prevalences of dementia and cognitive impairment among older people in sub-Saharan Africa: a systematic review. Bull World Health Organ 2013;91:773–83. doi: 10.2471/BLT.13. 118422.
Ren L, Zheng Y, Wu L, et al. Investigation of the prevalence of cognitive impairment and its risk factors within the elderly population in Shanghai, China. Sci Rep 2018;8:1–9. doi: 10.1038/s41598-018-21983-w.
Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J Psychiatr Res 2015;60:56–64. doi: 10.1016/j.jpsychires. 2014.10.003.
Gomez-Pinilla F, Hillman C. The influence of exercise on cognitive abilities. Compr Physiol 2013;3:403–28.
Htut TZC, Hiengkaew V, Jalayondeja C, Vongsirinavarat M. Effects of physical, virtual reality-based, and brain exercise on physical, cognition, and preference in older persons: a randomized controlled trial. Eur Rev Aging Phys Act 2018;15:1–12. doi: 10.1186/s11556-018-0199-5.
Zhang T, Lin CC, Yu TC, Sun J, Hsu WC, Wong AMK. Fun cube based Brain Gym cognitive function assessment system. Comput Biol Med 2017;84:1–8. doi:10.1016/ j.compbiomed.2017.03. 003.
Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW. Association of daily intellectual activities with lower risk of incident dementia among older Chinese adults. JAMA Psychiatry 2018;75:697–703. doi: 10.1001/jamapsychiatry. 2018. 0657.
Erickson KI, Miller DL, Roecklein KA. The aging hippocampus: interactions between exercise, depression, and BDNF. Neuroscientist 2012;18:82-97. doi: 10.1177/ 1073858410397054.
Byun JE, Kang EB. The effects of senior brain health exercise program on basic physical fitness, cognitive function and BDNF of elderly women - a feasibility study. J Exerc Nutrition Biochem. 2016;20:8-18. http://dx.doi.org/ 10.20463/jenb.2016.06.20.2.2.
Huang T, Larsen KT, Ried-Larsen M, Møller NC, Andersen LB. The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review. Scand J Med Sci Sport 2014;24:1–10. doi: 10.1111/sms.12069.
Schega L, Peter B, Brigadski T, et al. Effect of intermittent normobaric hypoxia on aerobic capacity and cognitive function in older people. J Sci Med Sport 2016;19:941-5. doi: 10.1016/ j.jsams.2016.02.012.
Trzepacz PT, Hochstetler H, Wang S, Walker B, Saykin AJ and for the Alzheimer’s Disease Neuroimaging Initiative. Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination for assessment of mild cognitive impairment in older adults. BMC Geriatrics 2015;15:107. DOI: 10.1186/ s12877-015-0103-3.
Gonzalez-Wallace M. Super body super brain: the workout that does it all. New York : Harper Collins; 2019.
Zoladz JA. The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol 2010;61: 533–41.
Ludyga S, Gerber M, Brand S, Holsboer-Trachsler E, Pühse U. Acute effects of moderate aerobic exercise on specific aspects of executive function in different age and fitness groups: a meta-analysis. Psychophysiology 2016;53:1611–26. doi: 10.1111/psyp.12736.
World Health Organization. Global recommendations on physical activity for health. Geneva; World Health Organization; 2010.
Mandolesi L, Polverino A, Montuori S, et al. Effects of physical exercise on cognitive functioning and wellbeing: biological and psychological benefits. Front Psychol 2018;9: 1–11. doi: 10.3389/fpsyg.2018.00509.
Rasmussen P, Brassard P, Adser H, Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol 2009;94:1062-9. doi: 10.1113/ expphysiol.2009. 048512.
Sleiman SF, Henry J, Al-Haddad R, et al. Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body ?- hydroxybutyrate. Elife 2016;5: pii: e15092. doi: 10.7554/eLife.15092.
Nishiguchi S, Yamada M, Tanigawa T, et al. A 12-week physical and cognitive exercise program can improve cognitive function and neural efficiency in community-dwelling older adults: a randomized controlled trial. J Am Geriatr Soc 2015;63:1355-63. doi: 10.1111/ jgs.13481.
Sanders LMJ, Hortobágyi T, La Bastide-van Gemert S, van der Zee EA, van Heuvelen MJG. Dose-response relationship between exercise and cognitive function in older adults with and without cognitive impairment: a systematic review and meta-analysis. PLoS One 2019;14:e0210036. doi: 10.1371/journal.pone. 0210036.
Öhman H, Savikko N, Strandberg TE, Pitkälä KH. Effect of physical exercise on cognitive performance in older adults with mild cognitive impairment or dementia: a systematic review. Dement Geriatr Cogn Disord 2014;38: 347-65. doi: 10.1159/000365388.
Basso JC, Suzuki WA. The effects of acute exercise on mood, cognition, neurophysiology, and neurochemical pathways: a review. Brain Plast 2017;2:127-52. doi: 10.3233/BPL-160040.
Brown BM, Peiffer JJ, Sohrabi HR, et al. Intense physical activity is associated with cognitive performance in the elderly. Transl Psychiatry 2012;2:e191. doi: 10.1038/tp.2012. 118.10.1038/tp.2012.118.