pISSN 1907-3062 | eISSN 2407-2230 | Universa Medicina content is searchable on DOAJ, Google Scholar, and OAI

Effectiveness of Piper betle leaf infusion as a palpebral skin antiseptic

Husnun Amalia, Ratna Sitompul, Johan Hutauruk, Andrianjah Andrianjah, Abdul Mun’im
Submission date: Monday, 29 February 2016
Published date: Saturday, 29 August 2009

Article Metrics

Abstract viewed: 475 times

Abstract


The goal of an antiseptic is to eliminate or greatly reduce the number of microorganisms in the surgical field at the time of the surgery. The objective of this study was to verify the effectiveness of 20% Piper betle leaf infusion as an antiseptic solution in pre-surgery cataract patients. A clinical trial with partner-matching design was conducted on 31 pairs of eyelids. From each pair of eyelids, one eyelid was asigned to the Piper betle infusion group and the opposite one to the povidone-iodine group. The microorganisms were collected by swab from the patient’s palpebral skin, inoculated on nutrient agar, and incubated at 37oC for 20 hours. The antiseptic effectiveness was measured by counting the microbial colonies before and after administration of the antiseptic solutions. This study demonstrates that the mean colony counts after application of 20% Piper betle leaf infusion showed a significant reduction of 27-100% compared with those before administration (p=0.001). Mean colony counts after 10% povidone-iodine administration showed a significant reduction of 88-100% compared with the mean counts before the solution was applied (p=0.000). The 20% Piper betle infusion has an antiseptic potential. Nevertheless, the 10% povidone-iodine solution has more effective antiseptic capability.

Keywords


Antiseptic; palpebral skin; Piper betle leaf infusion; povidone-iodine

Full Text:

PDF

References


Department of Health, Republic of Indonesia. Results of the basic health survey 2007. Jakarta: Board for Research and Development, Department of Health, Republic of Indonesia;2008.

Lister J. On the antiseptic principle in the practice of surgery. The Lancet 1867 cited by Connor JJ, Connor JTH. Being Lister: ethos and Victorian medical discourse. J Med Ethics 2008;34:3–10.

Hefny C, Edelhauser H. Surgical pharmacology: intraocular solutions and drugs used for cataract surgery. In: Buratto L, Liliana W, Zanini M, Apple D, editors. Pacoemulsification principles and techniques. 10th ed. Thorofare: Slack;2003.p.219-20.

Fergsuon A, Scott J, McGavigan J, Elton R, McLean J, Schmidt U, et al. Comparison of 5% povidone-iodine solution against 1% povidon-iodine solution in preoperative cataract surgery antisepsis: a prospective randomised double blind study. Br J Opthalmol 2003;87:163-7.

Surgery for cataract. In: Ophthalmology AA, editor. Lens and cataract. San Francisco: American Academy of Ophthalmology;2005.p.89-97.

Bausz M, Fodor E, Resch MD, Kristof K. Bacterial contamination in the anterior chamber after povidone-iodine application and the effect of the lens implantation device. J Cataract Refract Surg 2006;32:1691-5.

de Kaspar HM, Chang RT, Singh K, Egbert PR, Blumenkranz MS, Ta CN. Prospective randomized comparison of 2 different methods of 5% povidone-iodine applications for anterior segment intraocular surgery. Arch Ophthalmol 2005;123:161-5.

Yoshida K, Sakurai Y, Kawahara S, Takeda T, Ishikawa T, Murakami T, et al. Anaphylaxis to polyvinylpyrrolidone in povidone-iodine for impetigo contagiosum in a boy with atopic dermatitis. Int Arch Allergy Immunol 2008;146: 169–73.

Moeljanto RD, Mulyono. Khasiat dan manfaat daun sirih. 1st ed. Depok: Agromedia Pustaka; 2003.

Nalina T, Rahim ZHA. 2007. The crude aqueous extract of Piper betle L. and its anti bacterial effect towards Streptococcus mutans. Am J Biochem Biotechnol 2007;3:10–5.

Chang MC, Uang BJ, Wu HL, Lee JJ, Hahn LJ, Jeng JH. A major phenolic compound in Piper betle leaves. Br J Pharmacol 2002;135:619–30.

Jeng JH, Wang YJ, Chang WH. Reactive oxygen species are crucial for hydroxychavicol toxicity toward KB epithelial cells. Cell Mol Life Sci 2004;61:83–96.

Razak FA, Rahim ZH. The anti-adherence effect of Piper betle and Psidium guajava extracts on the adhesion of early settlers in dental plaque to saliva-coated glass surfaces. J Oral Sci 2003;45:201–6.

Nasagewa M, Hayashi H, Nakayoshi T. In vitro evaluation of skin sensitivity of povidone-iodine and other antiseptics using a three-dimensional human skin model. Dermatology 2002;204:109-13.

McGreal GT, Joy A, Manning B, Kelly JL, O’Donnell JA, Kirwan WWO, et al. Antiseptic Wick: Does it reduce the incidence of wound infection following appendectomy? World J Surg 2002;26:631-4.

Tortora GJ, Funke BR, Case CL Microbiology. 6th ed. California: Addison Wesley Longman; 1998.

Murnikusumawatie R. Perbandingan daya antibakteri rebusan dan minyak atsiri daun sirih (Piper betle L.) terhadap Staphylococcus aureus dan Pseudomonas aeruginosa yang diisolasi dari ulkus kornea [SpM thesis]. Jakarta: FKUI; 2007.

de Kaspar HM, Chang RT, Singh K, Egbert PR, Blumenkranz MS, Ta CN. Prospective randomized comparison of 2 different methods of 5% povidone-iodine applications for anterior segment intraocular surgery. Arch Ophthalmol 2005;123:161-5.

Ciulla TA, Starr MB, Masket S. Bacterial endophthalmitis prophylaxis for cataract surgery. An evidence-based update. Ophthalmology 2002;109:13-24.

Houang E, Gilmore O, Reid C, Shaw E. Absence of bacterial resistance to povidone-iodine. J Clin Path 1976;29:752-5.

Suriatmini S. Pengaruh cara sterilisasi terhadap stabilitas rebusan daun sirih [S.Si Skripsi]. Depok: Universitas Indonesia; 2005.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2009 Husnun Amalia, Ratna Sitompul, Johan Hutauruk, Andrianjah Andrianjah, Abdul Mun’im

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Creative Commons License
Universa Medicina by Faculty of Medicine, Trisakti University is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Based on a work at https://univmed.org/ejurnal/index.php/medicina/


                Scilit